The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the
unfolded protein response (UPR) through the activation of specialized sensors including …

The endoplasmic reticulum (ER) is an important organelle involved in protein quality control
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …

Alzheimer's disease (AD) is a progressive neurodegenerative condition that leads to
memory loss and cognitive impairment over time. It is characterized by protein misfolding as …

The endoplasmic reticulum (ER) is a dynamic and multifunctional organelle responsible for
protein biosynthesis, folding, assembly and modifications. Loss of protein folding regulation …

One of the early cellular responses to endoplasmic reticulum (ER) stress is the activation of
the unfolded protein response (UPR). ER stress and the UPR are both implicated in …

The endoplasmic reticulum (ER) is a multifunctional intracellular organelle supporting many
processes required by virtually every mammalian cell, including cardiomyocytes. It performs …

The endoplasmic reticulum (ER) is an intracellular organelle consisting of a membranous
labyrinth network that extends throughout the cytoplasm of the cell and is contiguous with …

Cellular mechanisms governing redox homeostasis likely involve their integration with other
stresses. Endoplasmic reticulum (ER) stress triggers complex adaptive or proapoptotic …

Cardiovascular disease constitutes a major and increasing health burden in developed
countries. Although treatments have progressed, the development of novel treatments for …

The endoplasmic reticulum (ER) is a central organelle entrusted with lipid synthesis, protein
folding and protein maturation. It is endowed with a quality control system that facilitates the …