Background Genome-wide association studies (GWASs) and global profiling of gene
expression (microarrays) are two major technological breakthroughs that allow hypothesis …

Prostate cancer is the most common cancer in men in Europe and the United States. The
genetic heritability of prostate cancer is contributed to by both rarely occurring genetic …

Background Recent advances in high-throughput genotyping have made possible
identification of genetic variants associated with increased risk of developing prostate …

Prostate cancer (PCa) is the second most frequently diagnosed malignancy in men.
Genome-wide association studies (GWAS) has been highly successful in discovering …

Background Pathway analysis of large-scale omics data assists us with the examination of
the cumulative effects of multiple functionally related genes, which are difficult to detect …

Genome-wide association studies (GWAS) have revolutionized the field of cancer genetics,
but the causal links between increased genetic risk and onset/progression of disease …

While genome-wide association studies (GWAS) have revealed thousands of disease risk
single nucleotide polymorphisms (SNPs), their functions remain largely unknown. Recent …

Genome-wide association studies (GWAS) have identified multiple single nucleotide
polymorphisms (SNPs) associated with prostate cancer risk. However, whether these …

BACKGROUND The majority of established prostate cancer (PCa) risk‐associated single
nucleotide polymorphisms (SNPs) identified from genome‐wide association studies do not …

Heritability is one of the strongest risk factors of prostate cancer, emphasizing the
importance of the genetic contribution towards prostate cancer risk. To date, 86 established …