Therapeutic antibodies that target inflammatory cytokines in autoimmune diseases
Y Lai, C Dong - International immunology, 2016 - academic.oup.com
Inflammatory cytokines are key regulators of immune responses. Persistent and excessive
production of inflammatory cytokines underscores the development of autoimmune …
production of inflammatory cytokines underscores the development of autoimmune …
Biologics for targeting inflammatory cytokines, clinical uses, and limitations
P Rider, Y Carmi, I Cohen - International journal of cell biology, 2016 - Wiley Online Library
Proinflammatory cytokines are potent mediators of numerous biological processes and are
tightly regulated in the body. Chronic uncontrolled levels of such cytokines can initiate and …
tightly regulated in the body. Chronic uncontrolled levels of such cytokines can initiate and …
Cytokines in autoimmunity: role in induction, regulation, and treatment
KD Moudgil, D Choubey - Journal of Interferon & Cytokine …, 2011 - liebertpub.com
Cytokines play a pivotal role in the pathogenesis of autoimmune diseases. The precise
triggers for the breakdown of self-tolerance and the subsequent events leading to the …
triggers for the breakdown of self-tolerance and the subsequent events leading to the …
Selected cytokine pathways in rheumatoid arthritis
M Noack, P Miossec - Seminars in immunopathology, 2017 - Springer
Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction.
Cytokines play a key role in its pathogenesis. They contribute to the induction and …
Cytokines play a key role in its pathogenesis. They contribute to the induction and …
Cytokines that regulate autoimmunity
C Diveu, MJ McGeachy, DJ Cua - Current opinion in immunology, 2008 - Elsevier
Recent advances have revealed new insights in cytokine regulation of inflammatory
responses. TGFβ acting together with pro-inflammatory cytokines such as IL-6 promotes …
responses. TGFβ acting together with pro-inflammatory cytokines such as IL-6 promotes …
Developing connections amongst key cytokines and dysregulated germinal centers in autoimmunity
RA Sweet, SK Lee, CG Vinuesa - Current opinion in immunology, 2012 - Elsevier
Systemic autoimmunity owing to overactivity of Tfh and dysregulated germinal centers has
been described in mice and humans. Cytokines such as IL-21, IFN-γ, IL-6 and IL-17 are …
been described in mice and humans. Cytokines such as IL-21, IFN-γ, IL-6 and IL-17 are …
Cytokines and cytokine profiles in human autoimmune diseases and animal models of autoimmunity
M Kunz, SM Ibrahim - Mediators of inflammation, 2009 - Wiley Online Library
The precise pathomechanisms of human autoimmune diseases are still poorly understood.
However, a deepened understanding of these is urgently needed to improve disease …
However, a deepened understanding of these is urgently needed to improve disease …
A cytokine-centric view of the pathogenesis and treatment of autoimmune arthritis
B Astry, E Harberts, KD Moudgil - Journal of interferon & cytokine …, 2011 - liebertpub.com
Cytokines are immune mediators that play an important role in the pathogenesis of
rheumatoid arthritis (RA), an autoimmune disease that targets the synovial joints. The …
rheumatoid arthritis (RA), an autoimmune disease that targets the synovial joints. The …
Targeting cytokines of the interleukin-12 family in autoimmunity
BY Kang, TS Kim - Current medicinal chemistry, 2006 - ingentaconnect.com
In the past, autoimmunity was thought to be mediated by antibodies and immune complexes.
It has now become clear that many autoimmune diseases, especially tissue specific, are T …
It has now become clear that many autoimmune diseases, especially tissue specific, are T …
Interleukin 23 and autoimmune diseases: current and possible future therapies
Purpose IL-23 is a central proinflammatory cytokine with a wide range of influence over
immune response. It is implicated in several autoimmune diseases due to the infinite …
immune response. It is implicated in several autoimmune diseases due to the infinite …