Expressed hypervariable polymorphism of apolipoprotein (a).

MI Kamboh, RE Ferrell, BA Kottke - American journal of human …, 1991 - ncbi.nlm.nih.gov
Elevated plasma lipoprotein (a)(LP (a] levels are an independent predictor of the
development of premature atherosclerosis in humans. The LP (a) particle consists of two …

Polymorphic forms of human apolipoprotein [a]: inheritance and relationship of their molecular weights to plasma levels of lipoprotein [a].

JW Gaubatz, KI Ghanem, J Guevara, ML Nava… - Journal of Lipid …, 1990 - ASBMB
The plasma concentration of human lipoprotein [a], Lp [a], is highly correlated with coronary
artery disease. The protein moiety of Lp [a], apoLp [a], consists of two apoproteins, apo [a] …

The apolipoprotein (a) gene resides on human chromosome 6q26–27, in close proximity to the homologous gene for plasminogen

SL Frank, I Klisak, RS Sparkes, T Mohandas… - Human genetics, 1988 - Springer
Summary Apolipoprotein (a)[apo (a)], the glycoprotein associated with the lipoprotein (a)[Lp
(a)] subfraction of plasma lipoproteins, has been shown to exhibit heritable molecular weight …

Plasma lipoprotein (a) levels and expression of the apolipoprotein (a) gene are dependent on the nucleotide polymorphisms in its 5'-flanking region.

K Suzuki, M Kuriyama, T Saito… - The Journal of clinical …, 1997 - Am Soc Clin Investig
The apolipoprotein (a)(apo [a]) gene encodes a protein component of lipoprotein (a)[Lp (a)]
whose plasma levels vary widely among individuals. Hyper-Lp (a)-emia constitutes a risk …

Sequence polymorphisms in the apolipoprotein (a) gene. Evidence for dissociation between apolipoprotein (a) size and plasma lipoprotein (a) levels.

JC Cohen, G Chiesa, HH Hobbs - The Journal of clinical …, 1993 - Am Soc Clin Investig
Apolipoprotein (a)[apo (a)], an apolipoprotein unique to lipoprotein (a)[Lp (a)], is highly
polymorphic in size. Previous studies have indicated that the size of the apo (a) gene tends …

The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentration

HG Kraft, S Köchl, HJ Menzel, C Sandholzer… - Human genetics, 1992 - Springer
Abstract Lipoprotein (a)[Lp (a)] is a quantitative trait in human plasma. Lp (a) consists of a
low-density lipoprotein and the plasminogen-related apolipoprotein (a)[apo (a)]. The apo (a) …

Variation in lipoprotein (a) concentration associated with different apolipoprotein (a) alleles.

YF Perombelon, AK Soutar… - The Journal of clinical …, 1994 - Am Soc Clin Investig
Plasma lipoprotein (a)(Lp (a)) concentrations vary considerably between individuals. To
examine the variation for products of the same and different apolipoprotein (a)(apo (a)) …

Apolipoprotein (a) gene accounts for greater than 90% of the variation in plasma lipoprotein (a) concentrations.

E Boerwinkle, CC Leffert, J Lin… - The Journal of …, 1992 - Am Soc Clin Investig
Plasma lipoprotein (a)[Lp (a)], a low density lipoprotein particle with an attached
apolipoprotein (a)[apo (a)], varies widely in concentration between individuals. These …

Molecular basis for “null” lipoprotein (a) phenotypes and the influence of apolipoprotein (a) size on plasma lipoprotein (a) level in the baboon.

AL White, JE Hixson, DL Rainwater… - Journal of Biological …, 1994 - Elsevier
High plasma levels of lipoprotein (a)(Lp (a)) and its unique apolipoprotein, apo (a), are an
independent risk factor for cardiovascular disease. Plasma Lp (a) levels vary over a 1000 …

A pentanucleotide repeat polymorphism in the 5'control region of the apolipoprotein (a) gene is associated with lipoprotein (a) plasma concentrations in Caucasians.

M Trommsdorff, S Köchl, A Lingenhel… - The Journal of …, 1995 - Am Soc Clin Investig
The enormous interindividual variation in the plasma concentrations of the atherogenic
lipoprotein (a)[Lp (a)] is almost entirely controlled by the apo (a) locus on chromosome 6q26 …