[HTML][HTML] Organization and regulation of gene transcription
P Cramer - Nature, 2019 - nature.com
The regulated transcription of genes determines cell identity and function. Recent structural
studies have elucidated mechanisms that govern the regulation of transcription by RNA …
studies have elucidated mechanisms that govern the regulation of transcription by RNA …
[HTML][HTML] RNA polymerase II elongation through chromatin
G Orphanides, D Reinberg - Nature, 2000 - nature.com
The machinery that transcribes protein-coding genes in eukaryotic cells must contend with
repressive chromatin structures in order to find its target DNA sequences. Diverse arrays of …
repressive chromatin structures in order to find its target DNA sequences. Diverse arrays of …
Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins
WS Dynan, R Tjian - Nature, 1985 - nature.com
The enzymatic machinery that carries out RNA synthesis provides the cell with the means to
adjust the patterns of transcription in response to environmental and developmental signals …
adjust the patterns of transcription in response to environmental and developmental signals …
An RNA polymerase II holoenzyme responsive to activators
AJ Koleske, RA Young - Nature, 1994 - nature.com
Abstract RNA POLYMERASE II requires multiple general transcription factors to initiate site-
specific transcription1–3. These proteins can assemble in an ordered fashion onto promoter …
specific transcription1–3. These proteins can assemble in an ordered fashion onto promoter …
[HTML][HTML] RNA polymerase I structure and transcription regulation
Transcription of ribosomal RNA by RNA polymerase (Pol) I initiates ribosome biogenesis
and regulates eukaryotic cell growth. The crystal structure of Pol I from the yeast …
and regulates eukaryotic cell growth. The crystal structure of Pol I from the yeast …
[HTML][HTML] Structural basis of RNA polymerase III transcription initiation
RNA polymerase (Pol) III transcribes essential non-coding RNAs, including the entire pool of
transfer RNAs, the 5S ribosomal RNA and the U6 spliceosomal RNA, and is often …
transfer RNAs, the 5S ribosomal RNA and the U6 spliceosomal RNA, and is often …
RNA polymerase II C-terminal domain required for enhancer-driven transcription
HP Gerber, M Hagmann, K Seipel, O Georgiev… - Nature, 1995 - nature.com
Abstract THE RNA polymerase II carboxy-terminal domain (CTD) consists of tandem repeats
of the sequence Tyr-Ser-Pro-Thr-Ser-Pro-Ser1–3. The CTD may participate in activated …
of the sequence Tyr-Ser-Pro-Thr-Ser-Pro-Ser1–3. The CTD may participate in activated …
Structural basis of eukaryotic gene transcription
H Boeger, DA Bushnell, R Davis, J Griesenbeck… - FEBS …, 2005 - Wiley Online Library
An RNA polymerase II promoter has been isolated in transcriptionally activated and
repressed states. Topological and nuclease digestion analyses have revealed a dynamic …
repressed states. Topological and nuclease digestion analyses have revealed a dynamic …
Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 Å resolution
AL Gnatt, P Cramer, J Fu, DA Bushnell, RD Kornberg - Science, 2001 - science.org
The crystal structure of RNA polymerase II in the act of transcription was determined at 3.3 Å
resolution. Duplex DNA is seen entering the main cleft of the enzyme and unwinding before …
resolution. Duplex DNA is seen entering the main cleft of the enzyme and unwinding before …
RNA polymerase specificity and the control of growth
A Travers - Nature, 1976 - nature.com
RNA polymerase is an allosteric enzyme whose activity and specificity are controlled by
interaction with a nucleotide, tRNA and proteins. In E. coli the availability of these effectors …
interaction with a nucleotide, tRNA and proteins. In E. coli the availability of these effectors …