Endothelial cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential susceptibilities to local cellular activity

M Ehrbar, A Metters, P Zammaretti, JA Hubbell… - Journal of controlled …, 2005 - Elsevier
A number of vascular therapies could benefit from advanced methods for presentation of
angiogenic growth factors, including growth of endothelium on small caliber vascular grafts …

Cell-Demanded Liberation of VEGF121 From Fibrin Implants Induces Local and Controlled Blood Vessel Growth

M Ehrbar, VG Djonov, C Schnell, SA Tschanz… - Circulation …, 2004 - Am Heart Assoc
Although vascular endothelial growth factor (VEGF) has been described as a potent
angiogenic stimulus, its application in therapy remains difficult: blood vessels formed by …

Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF164

V Sacchi, R Mittermayr, J Hartinger… - Proceedings of the …, 2014 - National Acad Sciences
Clinical trials of therapeutic angiogenesis by vascular endothelial growth factor (VEGF) gene
delivery failed to show efficacy. Major challenges include the need to precisely control in …

Covalently conjugated VEGF–fibrin matrices for endothelialization

AH Zisch, U Schenk, JC Schense… - Journal of Controlled …, 2001 - Elsevier
Vascular endothelial growth factor (VEGF) is a key factor in endothelial cell biology and
blood vessel formation and a candidate therapeutic for the stimulation of angiogenesis …

The role of actively released fibrin-conjugated VEGF for VEGF receptor 2 gene activation and the enhancement of angiogenesis

M Ehrbar, SM Zeisberger, GP Raeber, JA Hubbell… - Biomaterials, 2008 - Elsevier
A major challenge for therapeutic delivery of angiogenic agents such as vascular
endothelial growth factor (VEGF) is to achieve sustained, low dose signaling leading to …

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A165

S Traub, J Morgner, MM Martino, S Höning, MA Swartz… - Biomaterials, 2013 - Elsevier
Synergy in the downstream signaling pathways of the vascular endothelial growth factor
receptor-2 (VEGFR-2) and the integrin αvβ3 is critical for blood vessel formation. Thus …

Soluble forms of VEGF receptor‐1 and ‐2 promote vascular maturation via mural cell recruitment

S Lorquet, S Berndt, S Blacher, E Gengoux… - The FASEB …, 2010 - Wiley Online Library
Two soluble forms of vascular endothelial growth factor (VEGF) receptors, sVEGFR‐1 and
sVEGFR‐2, are physiologically released and overproduced in some pathologies. They are …

VEGF gene transfer into endothelial cells for vascular prosthesis

RE Pratt, VJ Dzau - US Patent 5,785,965, 1998 - Google Patents
2. Background Vascular disease affects a large segment of the human population, and is the
leading cause of death in the United States. Each year in the US 800,000 individuals survive …

The effect of vascular endothelial growth factor (VEGF) presentation within fibrin matrices on endothelial cell branching

SM Anderson, SN Siegman, T Segura - Biomaterials, 2011 - Elsevier
Vascular endothelial growth factor (VEGF) has been extensively investigated to promote
vascularization at damaged or diseased sites and in tissue implants. Here we are interested …

Cell‐demanded release of VEGF from synthetic, biointeractive cell‐ingrowth matrices for vascularized tissue growth

AH Zisch, MP Lutolf, M Ehrbar, GP Raeber… - The FASEB …, 2003 - Wiley Online Library
Local, controlled induction of angiogenesis remains a challenge that limits tissue
engineering approaches to replace or restore diseased tissues. We present a new class of …