Several papers have claimed that mitochondria contain nitric oxide synthase (NOS) and
make nitric oxide (NO•) in amounts sufficient to affect mitochondrial respiration. However, we …

It is more than 10 years now that mitochondria are suspected to be sources of nitric oxide
(NO). This hypothesis is intriguing since NO has multiple targets within the organelle and it is …

The production of NO⋅ by mitochondria was investigated by electron paramagnetic
resonance using the spin-trapping technique, and by the oxidation of oxymyoglobin. Percoll …

Nitric oxide (NO) is produced in mam‐mals by different isoforms of NO synthase (NOS), in‐
cluding the constitutive mitochondrial enzyme (mtNOS). Here we demonstrate that the …

Nitric oxide (NO) and its derivative peroxynitrite (ONOO−) inhibit mitochondrial respiration by
distinct mechanisms. Low (nanomolar) concentrations of NO specifically inhibit cytochrome …

Biological systems that produce or are exposed to nitric oxide (NO⋅) exhibit changes in the
rate of oxygen free radical production. Considering that mitochondria are the main …

To elucidate the role of nitric oxide (NO) in the regulation of mitochondrial function, the effect
of NO on energy transfer reactions was examined under different oxygen tensions …

The effects of endogenous production of NO•, catalysed by the mitochondrial nitric oxide
synthase (NOS), on mitochondrial metabolism were studied. The respiratory rates of intact …

The effect of O2 concentration on mitochondrial nitric oxide synthase (mtNOS) activity and
on O2− production was determined in rat liver, brain, and kidney submitochondrial …

In the present study we show the existence of a functional nitric oxide synthase (NOS) in rat
liver mitochondria. The enzyme uses l-arginine (l-arg) to produce nitric oxide (NO) and l …