Promyelocytic leukemia-retinoic acid receptor alpha (PML-RARα) expression in acute
promyelocytic leukemia (APL) impairs transforming growth factor beta (TGFβ) signaling …

Background Halofuginone (HF) is a low-molecular-weight alkaloid that has been
demonstrated to interfere with Metalloproteinase-2 (MMP-2) and Tumor Growth Factor-β …

The present study aimed to explore the effects of antifibrotic agent halofuginone on uterine
leiomyomas (ULs) cells. The survival of the uterine smooth muscle (UtSMC) cells and UL …

Malignant mesothelioma is a rare but aggressive form of malignancy, which is difficult to
diagnose and is resistant to current chemotherapeutic treatment options. Molecular …

The small-molecule alkaloid halofuginone (HF) is obtained from febrifugine. Recent studies
on HF have aroused widespread attention owing to its universal range of noteworthy …

Purpose It was reported that halofuginone has inhibitory effects on transforming growth
factor-beta (TGF-β) signaling pathway. The study was aimed to: 1) evaluate the antitumor …

Halofuginone (HF) is extracted from Dichroa febrifuga, a plant used in traditional medicine.
We report that the HF extract inhibits the growth of breast cancer cells and induces the …

The Akt/mTORC1 pathway plays a central role in the activation of Warburg effect in cancer.
Here, we present for the first time that halofuginone (HF) treatment inhibits colorectal cancer …

Background 5-aminolevulinic acid-mediated PDT (ALA-PDT) has been used in a variety of
skin diseases including cSCC (cutaneous squamous cell carcinoma). Halofuginone (HL) is …

Osteosarcoma is the main malignant primary bone tumor in children and adolescents for
whom the prognosis remains poor, especially when metastases are present at diagnosis …