Role of BRAF in thyroid oncogenesis
LM Caronia, JE Phay, MH Shah - Clinical cancer research, 2011 - AACR
BRAF, a cytoplasmic serine–threonine protein kinase, plays a critical role in cell signaling as
an activator within the mitogen-activated protein kinase (MAPK) pathway. The most common …
an activator within the mitogen-activated protein kinase (MAPK) pathway. The most common …
[PDF][PDF] The role of BRAF in the pathogenesis of thyroid carcinoma
DD Li, YF Zhang, HX Xu… - Front Biosci (Landmark Ed …, 2015 - article.imrpress.com
1. ABSTRACT BRAF is a cytoplasmic serine-threonine protein kinasethat plays a critical role
in the MAPK signaling pathway. BRAF is the only member of the RAF family activated by …
in the MAPK signaling pathway. BRAF is the only member of the RAF family activated by …
[HTML][HTML] Targeting BRAF in thyroid cancer
AV Espinosa, L Porchia, MD Ringel - British journal of cancer, 2007 - nature.com
Activating mutations in the gene encoding BRAF are the most commonly identified
oncogenic abnormalities in papillary thyroid cancer. In vitro and in vivo models have …
oncogenic abnormalities in papillary thyroid cancer. In vitro and in vivo models have …
BRAF is a therapeutic target in aggressive thyroid carcinoma
G Salvatore, V De Falco, P Salerno, TC Nappi… - Clinical Cancer …, 2006 - AACR
Purpose: Oncogenic conversion of BRAF occurs in∼ 44% of papillary thyroid carcinomas
and 24% of anaplastic thyroid carcinomas. In papillary thyroid carcinomas, this mutation is …
and 24% of anaplastic thyroid carcinomas. In papillary thyroid carcinomas, this mutation is …
[HTML][HTML] BRAF mutation in thyroid cancer
M Xing - Endocrine-related cancer, 2005 - erc.bioscientifica.com
Genetic alteration is the driving force for thyroid tumorigenesis and progression, based upon
which novel approaches to the management of thyroid cancer can be developed. A recent …
which novel approaches to the management of thyroid cancer can be developed. A recent …
Targeting BRAFV600E in thyroid carcinoma: therapeutic implications
CS Mitsiades, J Negri, C McMullan, DW McMillin… - Molecular cancer …, 2007 - AACR
B-Raf is an important mediator of cell proliferation and survival signals transduced via the
Ras-Raf-MEK-ERK cascade. BRAF mutations have been detected in several tumors …
Ras-Raf-MEK-ERK cascade. BRAF mutations have been detected in several tumors …
Biochemical and molecular characterization of the novel BRAFV599Ins mutation detected in a classic papillary thyroid carcinoma
Activating mutations of the BRAF gene are the most common genetic alterations in papillary
thyroid carcinomas (PTCs) and the T1799A transversion, resulting in BRAF V600E …
thyroid carcinomas (PTCs) and the T1799A transversion, resulting in BRAF V600E …
Prevalence, Tumorigenic Role, and Biochemical Implications of Rare BRAF Alterations
S Barollo, R Pezzani, A Cristiani, M Redaelli… - Thyroid, 2014 - liebertpub.com
Background: Papillary thyroid carcinoma (PTC) is the most common malignant tumor of the
thyroid gland, accounting for 74–80% of all thyroid cancers. The 1799T> A transversion is an …
thyroid gland, accounting for 74–80% of all thyroid cancers. The 1799T> A transversion is an …
BRAF mutation in papillary thyroid carcinoma: pathogenic role and clinical implications
KT Tang, CH Lee - Journal of the chinese medical association, 2010 - journals.lww.com
Papillary thyroid cancer (PTC) is the most common endocrine malignancy, accounting for 85–
90% of all thyroid cancers. Genetic alternations involving the mitogen-activated protein …
90% of all thyroid cancers. Genetic alternations involving the mitogen-activated protein …
Functional characterization of the novel T599I-VKSRdel BRAF mutation in a follicular variant papillary thyroid carcinoma
Context: Mutations in BRAF are rare in the follicular variant of papillary thyroid carcinoma
(FV-PTC). Objective: We identified and functionally characterized a novel T599I-VKSR (600 …
(FV-PTC). Objective: We identified and functionally characterized a novel T599I-VKSR (600 …
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