Natural killer (NK) cells were originally described on a functional basis, according to their
ability to lyse certain tumors in the absence of prior stimulation. However, neither their origin …

Natural killer (NK) cells play a key role in antiviral and tumour immunity. In the setting of HIV
infection, accumulating evidence implicates NK cells as critical contributors to immune …

NK cells can kill transformed, infected and stressed cells while most normal cells are spared.
NK cells are activated by various endogenous self‐ligands, some of which are actually …

Despite the absence of antigen-specific receptors at their surface, NK cells can selectively
eliminate virus-infected cells, tumor cells and allogenic cells. A dynamic and precisely …

NK cells attack cells lacking MHC class I, yet MHC class I-deficient mice have normal
numbers of NK cells with intact, albeit diminished, functions. Moreover, wild-type NK cells …

NK cells are cytotoxic components of innate lymphoid cells (ILC) that provide a first line of
defense against viral infections and contribute to control tumor growth and metastasis. Their …

NK cells have usually been defined as cells of the innate immune system, although they are
also involved in adaptative responses. These cells belong to the innate lymphocyte cells …

Althoughin vitrosystems have provided important information about the composition and
nature of various immune responses, understanding physiologically relevant function and …

A better understanding of the complex interactions between the immune system and tumour
cells from different origins has opened the possibility to design novel procedures of …

Human natural killer (NK) cells are functionally regulated by killer cell immunoglobulin-like
receptors (KIRs) and their interactions with HLA class I molecules. As KIR expression in a …