Nudix proteins catalyze the hydrolysis of pyrophosphate bonds in a variety of substrates and
are ubiquitous in all domains of life. The genome of an important opportunistic human …

Nudix proteins catalyse hydrolysis of pyrophosphate bonds in a variety of substrates and are
ubiquitous in all domains of life. Their widespread presence and broad substrate specificity …

Nudix pyrophosphatases, ubiquitous in all organisms, have not been well studied. Recent
implications that some of them may be involved in response to stress and in pathogenesis …

The nearly 50,000 known Nudix proteins have a diverse array of functions, of which the most
extensively studied is the catalyzed hydrolysis of aberrant nucleotide triphosphates. The …

Nudix hydrolase family proteins hydrolyse toxic by-products of cellular metabolism such as
mutagenic nucleoside triphosphates, sugar nucleotides and signalling molecules. We …

The common substrate structure for the functionally diverse Nudix protein superfamily is
nucleotide-diphosphate-X, where X is a large variety of leaving groups. The substrate …

Using nuclear magnetic resonance (NMR) based methods, including residual dipolar
coupling restraints, we have determined the solution structure of the hypothetical …

Many members of the nudix hydrolase family exhibit considerable substrate multispecificity
and ambiguity, which raises significant issues when assessing their functions in vivo and …

The PA0336 protein from Pseudomonas aeruginosa belongs to the family of widely
distributed Nudix pyrophosphohydrolases, which catalyze the hydrolysis of pyrophosphate …

Nudix hydrolases are found in all classes of organism and hydrolyse a wide range of
organic pyrophosphates, including nucleoside di-and triphosphates, dinucleoside and …