Abstract N‐palmitoyl‐ethanolamine (PEA) is an endogenous substance that was first
identified in lipid tissue extracts. It has been classified as a CB2 receptor agonist …

The production of nitric oxide (NO) from l-arginine is catalyzed by NO synthase (NOS), which
exists as the following three isoforms: endothelial (eNOS), neuronal (nNOS), and inducible …

Although the antinociceptive effects of N-palmitoyl-ethanolamine (PEA) were first
characterized nearly 50 years ago, the identity of the mechanism that mediates these actions …

Objective The antinociceptive pharmacological interaction between N-
palmitoylethanolamide (PEA) and morphine (MOR), as well as gabapentin (GBP), was …

BACKGROUND: The involvement of the l-arginine/nitric oxide (NO)/cyclic guanosine
monophosphate (cGMP) pathway in antinociception has been implicated as a molecular …

The antinociceptive effect of nitrous oxide (N2O) is dependent on nitric oxide (NO); however,
the next step in the pathway activated by NO is undetermined. The present study was …

NG‐nitro‐L‐arginine methyl ester (L‐NAME) has been used extensively as a paradigmatic
inhibitor of NO synthase and has been shown to cause antinociception in several …

In the current management of neuropathic pain, in addition to antidepressants and
anticonvulsants, the use of opioids is wide, despite their related and well-known issues. N …

The neural substrates and mechanisms mediating the antinociceptive effects of the
endogenous bioactive lipid, N-palmitoylethanolamide (PEA), require further investigation …

Despite the classical peripheral pronociceptive effect of noradrenaline (NA), recently studies
showed the involvement of NA in antinociceptive effect under immune system interaction. In …