The involvement of the nitric oxide–cyclic GMP pathway in the peripheral antinociception
induced by the COX-2 preferential inhibitor nimesulide was assessed by using the formalin …

Abstract Angiotensin-(1–7) is a bioactive component of the renin–angiotensin system that is
formed endogenously and induces nitric oxide release in several tissues. The l …

The present study was conducted to evaluate the local antinociceptive actions of EA and the
possible involvement of l-arginine/NO/cGMP/K ATP channel pathway in this effect using …

The literature shows that the monoterpenes are great candidates for the development of new
drugs for the treatment of various pathological processes, including painful conditions. The …

Palmitoylethanolamide (PEA) is an endogenous lipid that is thought to be involved in
endogenous protective mechanisms activated as a result of stimulation of inflammatory …

Rosemary essential oil (REO) has been used for several medical purposes. Previous
studies have shown the antinociceptive effect of the oil. This study aimed to investigate the …

It has already been shown that serotonin can release endocannabinoids at the spinal cord
level, culminating in inhibition of the dorsal horn. At the peripheral level, cannabinoid …

Background This study evaluated the antinociceptive action of α-(phenylalanyl)
acetophenone (PSAP) in mice. Methods Evaluated whether the serotonergic, adrenergic …

The l-arginine/nitric oxide/cyclic GMP pathway has been proposed as the mechanism of
action for peripheral antinociception concerning several groups of drugs, including opioids …

AIMS: Physical exercise is responsible for increasing the nociceptive threshold. The present
study aimed to investigate the involvement of the nitric oxide/CGMP/KATP pathway in …