Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals
JV van Vliet-Ostaptchouk, M den Hoed, J Luan… - Diabetologia, 2013 - Springer
Aims/hypothesis Genetic pleiotropy may contribute to the clustering of obesity and metabolic
conditions. We assessed whether genetic variants that are robustly associated with BMI and …
conditions. We assessed whether genetic variants that are robustly associated with BMI and …
Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals
Aims/hypothesis Genome-wide association studies have identified novel WHR and BMI
susceptibility loci. The aim of this study was to elucidate if any of these loci had an effect on …
susceptibility loci. The aim of this study was to elucidate if any of these loci had an effect on …
Gene× dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry
JA Nettleton, JL Follis, JS Ngwa… - Human molecular …, 2015 - academic.oup.com
Obesity is highly heritable. Genetic variants showing robust associations with obesity traits
have been identified through genome-wide association studies. We investigated whether a …
have been identified through genome-wide association studies. We investigated whether a …
Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies
OBJECTIVE Large-scale genome-wide association (GWA) studies have thus far identified
16 loci incontrovertibly associated with obesity-related traits in adults. We examined …
16 loci incontrovertibly associated with obesity-related traits in adults. We examined …
Genetic predisposition to obesity and lifestyle factors–the combined analyses of twenty-six known BMI-and fourteen known waist: hip ratio (WHR)-associated variants …
T Jääskeläinen, J Paananen, J Lindström… - British journal of …, 2013 - cambridge.org
Recent genome-wide association studies have identified multiple loci associated with BMI or
the waist: hip ratio (WHR). However, evidence on gene–lifestyle interactions is still scarce …
the waist: hip ratio (WHR). However, evidence on gene–lifestyle interactions is still scarce …
Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study
MD Fesinmeyer, KE North, MD Ritchie, U Lim… - …, 2013 - Wiley Online Library
Objective: Several genome–wide association studies (GWAS) have demonstrated that
common genetic variants contribute to obesity. However, studies of this complex trait have …
common genetic variants contribute to obesity. However, studies of this complex trait have …
[PDF][PDF] Harnessing tissue-specific genetic variation to dissect putative causal pathways between body mass index and cardiometabolic phenotypes
GM Leyden, CY Shapland, GD Smith… - The American Journal of …, 2022 - cell.com
Body mass index (BMI) is a complex disease risk factor known to be influenced by genes
acting via both metabolic pathways and appetite regulation. In this study, we aimed to gain …
acting via both metabolic pathways and appetite regulation. In this study, we aimed to gain …
Gene× physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry
Numerous obesity loci have been identified using genome-wide association studies. A UK
study indicated that physical activity may attenuate the cumulative effect of 12 of these loci …
study indicated that physical activity may attenuate the cumulative effect of 12 of these loci …
Dissecting the clinical relevance of polygenic risk score for obesity—a cross-sectional, longitudinal analysis
EK Choe, M Shivakumar, SM Lee, A Verma… - International Journal of …, 2022 - nature.com
Background Obesity is a global pandemic disease whose prevalence is increasing
worldwide. The clinical relevance of a polygenic risk score (PRS) for obesity has not been …
worldwide. The clinical relevance of a polygenic risk score (PRS) for obesity has not been …
Do genetic factors modify the relationship between obesity and hypertriglyceridemia? Findings from the GLACIER and the MDC studies
Background—Obesity is a major risk factor for dyslipidemia, but this relationship is highly
variable. Recently published data from 2 Danish cohorts suggest that genetic factors may …
variable. Recently published data from 2 Danish cohorts suggest that genetic factors may …