Fiber optic probe for polarized reflectance spectroscopy in vivo: Design and performance

A Myakov, L Nieman, L Wicky… - … of biomedical optics, 2002 - spiedigitallibrary.org
We present the design and construction of a fiber optic probe for elastic light scattering
spectroscopy in vivo with polarized excitation and polarization sensitive detection. The …

Characterizing mammalian cells and cell phantoms by polarized backscattering fiber-optic measurements

JR Mourant, TM Johnson, JP Freyer - Applied Optics, 2001 - opg.optica.org
Fiber-optic, polarized elastic-scattering spectroscopy techniques are implemented and
demonstrated as a method for determining both scatterer size and concentration in highly …

Optical sectioning using a fiber probe with an angled illumination-collection geometry: evaluation in engineered tissue phantoms

L Nieman, A Myakov, J Aaron, K Sokolov - Applied optics, 2004 - opg.optica.org
We present a fiber optic probe that combines polarized illumination and detection with an
angled distal probe geometry to detect the size-dependent scattering at a specific depth …

Reflectance spectroscopy with polarized light: is it sensitive to cellular and nuclear morphology

K Sokolov, R Drezek, K Gossage… - Optics …, 1999 - opg.optica.org
We present a method for selective detection of size-dependent scattering characteristics of
epithelial cells in vivo based on polarized illumination and polarization sensitive detection of …

Polarized angular dependent spectroscopy of epithelial cells and epithelial cell nuclei to determine the size scale of scattering structures

JR Mourant, TM Johnson, S Carpenter… - Journal of …, 2002 - spiedigitallibrary.org
An understanding of the relationship between tissue structures and light scattering from
tissue will help facilitate the development and acceptance of noninvasive optical diagnostics …

Analysis of changes in reflectance measurements on biological tissues subjected to different probe pressures

R Reif, MS Amorosino, KW Calabro… - … of biomedical optics, 2008 - spiedigitallibrary.org
Spectral reflectance measurements of biological tissues have been studied for early
diagnoses of several pathologies such as cancer. These measurements are often performed …

Monte Carlo analysis of single fiber reflectance spectroscopy: photon path length and sampling depth

SC Kanick, DJ Robinson, H Sterenborg… - Physics in Medicine & …, 2009 - iopscience.iop.org
Single fiber reflectance spectroscopy is a method to noninvasively quantitate tissue
absorption and scattering properties. This study utilizes a Monte Carlo (MC) model to …

Comparative study of polarized light propagation in biologic tissues

V Sankaran, JT Walsh Jr… - Journal of biomedical …, 2002 - spiedigitallibrary.org
We report the depolarization of light scattered by a variety of birefringent and nonbirefringent
tissues. We used Stokes polarimetry to investigate how scatterer structures in each tissue …

Depth-sensitive reflectance measurements using obliquely oriented fiber probes

AMJ Wang, JE Bender, J Pfefer… - … of biomedical optics, 2005 - spiedigitallibrary.org
Computer simulation is used to facilitate the design of fiber-probe geometries that enable
enhanced detection of optical signals arising from specific tissue depths. Obtaining …

In vivo quantification of the scattering properties of tissue using multi-diameter single fiber reflectance spectroscopy

F van Leeuwen-van Zaane, UA Gamm… - Biomedical optics …, 2013 - opg.optica.org
Multi diameter single fiber reflectance (MDSFR) spectroscopy is a non-invasive optical
technique based on using multiple fibers of different diameters to determine both the …