Engineering secondary metabolite production in hairy roots

S Chandra, R Chandra - Phytochemistry reviews, 2011 - Springer
Plants are a rich source of valuable secondary metabolites. Plant cell culture technologies
developed in the past as possible tools for secondary metabolites production. In most cases …

Hairy root culture for mass-production of high-value secondary metabolites

S Srivastava, AK Srivastava - Critical reviews in biotechnology, 2007 - Taylor & Francis
Plant cell cultivations are being considered as an alternative to agricultural processes for
producing valuable phytochemicals. Since many of these products (secondary metabolites) …

Metabolic engineering in hairy roots: An outlook on production of plant secondary metabolites

D Bagal, AA Chowdhary, S Mehrotra, S Mishra… - Plant Physiology and …, 2023 - Elsevier
Plants are one of the vital sources of secondary metabolites. These secondary metabolites
have diverse roles in human welfare, including therapeutic implication. Nevertheless …

Improvement of hairy root cultures and plants by changing biosynthetic pathways leading to pharmaceutical metabolites: strategies and applications

J Ludwig-Müller, L Jahn, A Lippert, J Püschel… - Biotechnology …, 2014 - Elsevier
A plethora of bioactive plant metabolites has been explored for pharmaceutical, food
chemistry and agricultural applications. The chemical synthesis of these structures is often …

New routes to plant secondary products

JD Hamill, AJ Parr, MJC Rhodes, RJ Robins… - Bio/technology, 1987 - nature.com
For some years, there has been great interest in the exploitation of plant cell cultures to
produce fine chemicals. With a few exceptions, progress in commercialization has been …

Hairy root cultures: a suitable biological system for studying secondary metabolic pathways in plants

P Sharma, H Padh… - Engineering in Life …, 2013 - Wiley Online Library
Hairy roots, a plant disease caused by Agrobacterium rhizogenes, show distinctive features
such as high growth rate, unlimited branching, and biochemical and genetic stability. Hairy …

Hairy root cultures for secondary metabolites production

L Pistelli, A Giovannini, B Ruffoni, A Bertoli… - Bio-farms for …, 2010 - Springer
Hairy roots (HRs) are differentiated cultures of transformed roots generated by the infection
of wounded higher plants with Agrobacterium rhizogenes. This pathogen causes the HR …

Hairy root type plant in vitro systems as sources of bioactive substances

MI Georgiev, AI Pavlov, T Bley - Applied microbiology and biotechnology, 2007 - Springer
Abstract “Hairy root” systems, obtained by transforming plant tissues with the “natural genetic
engineer” Agrobacterium rhizogenes, have been known for more than three decades. To …

Hairy root research: recent scenario and exciting prospects

S Guillon, J Tremouillaux-Guiller, PK Pati… - Current opinion in plant …, 2006 - Elsevier
High stability of the production of secondary metabolites is an interesting characteristic of
hairy root cultures. For 25 years, hairy roots have been investigated as a biological system …

Transformed root cultures for biotechnology

H Wysokinska, A Chmiel - Acta biotechnologica, 1997 - Wiley Online Library
This review is concerned with the application of hairy roots, ie plant roots formed from plant
cells after transformation by Agrobacterium rhizogenes for the production of bioactive …