Impaired bone regenerative effect of exosomes derived from bone marrow mesenchymal stem cells in type 1 diabetes

Y Zhu, Y Jia, Y Wang, J Xu, Y Chai - Stem Cells Translational …, 2019 - academic.oup.com
Stem cell-derived exosomes have exhibited promise for applications in tissue regeneration.
However, one major problem for stem cell-derived exosome therapies is identifying …

Exosomes from conditioned media of bone marrow-derived mesenchymal stem cells promote bone regeneration by enhancing angiogenesis

R Takeuchi, W Katagiri, S Endo, T Kobayashi - PLoS One, 2019 - journals.plos.org
Growth factors in serum-free conditioned media from human bone marrow-derived
mesenchymal stem cells (MSC-CM) are known to be effective in bone regeneration …

Immunoregulatory role of exosomes derived from differentiating mesenchymal stromal cells on inflammation and osteogenesis

F Wei, Z Li, R Crawford, Y Xiao… - Journal of tissue …, 2019 - Wiley Online Library
Bone marrow‐derived mesenchymal stem/stromal cells (BMSCs) can differentiate into bone‐
forming osteoblasts, playing a crucial role in bone regeneration. Exosomes are naturally cell …

Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing peripheral insulin resistance and relieving β-cell destruction

Y Sun, H Shi, S Yin, C Ji, X Zhang, B Zhang, P Wu… - ACS …, 2018 - ACS Publications
Exosomes are nanosized extracellular vesicles (EVs) that show great promise in tissue
regeneration and injury repair as mesenchymal stem cell (MSC). MSC has been shown to …

The effect of human bone marrow mesenchymal stem cell‐derived exosomes on cartilage repair in rabbits

H Yang, M Cong, W Huang, J Chen… - Stem Cells …, 2022 - Wiley Online Library
Mesenchymal stem cells (MSCs) have shown chondroprotective effects in cartilage repair.
However, side effects caused by MSC treatment limit their application in clinic. As a cell‐free …

Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway

M Yu, W Liu, J Li, J Lu, H Lu, W Jia, F Liu - Stem cell research & therapy, 2020 - Springer
Background Mesenchymal stem cell (MSC)-derived exosomes emerge as promising
candidates for treating delayed wound healing in diabetes due to the promotion of …

Exosomes secreted from hypoxia‐preconditioned mesenchymal stem cells prevent steroid‐induced osteonecrosis of the femoral head by promoting angiogenesis in …

N Yuan, Z Ge, W Ji, J Li - BioMed Research International, 2021 - Wiley Online Library
Recent studies have suggested that exosomes exert similar therapeutic effects to those of
mesenchymal stem cells (MSCs) in regenerative medicine and MSCs‐derived exosomes …

Exosomes secreted by umbilical cord blood‐derived mesenchymal stem cell attenuate diabetes in mice

R Sharma, M Kumari, S Mishra… - Journal of diabetes …, 2021 - Wiley Online Library
Mesenchymal stem cell (MSC) therapy is an innovative approach in diabetes due to its
capacity to modulate tissue microenvironment and regeneration of glucose‐responsive …

Osteogenically-induced exosomes stimulate osteogenesis of human adipose-derived stem cells

M Zhu, Y Liu, H Qin, S Tong, Q Sun, T Wang… - Cell and tissue …, 2021 - Springer
Exosomes exhibit great therapeutic potential in bone tissue engineering. The study aimed to
investigate whether the exosomes derived from human adipose-derived stem cells (hADSCs …

Exosomes from bone marrow mesenchymal stem cells enhance fracture healing through the promotion of osteogenesis and angiogenesis in a rat model of nonunion

L Zhang, G Jiao, S Ren, X Zhang, C Li, W Wu… - Stem cell research & …, 2020 - Springer
Background As important players in cell-to-cell communication, exosomes (exo) are
believed to play a similar role in promoting fracture healing. This study investigated whether …