Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-κB ligand signaling

KC Mansky, U Sankar, J Han, MC Ostrowski - Journal of Biological …, 2002 - ASBMB
Receptor activator of NF-κB ligand (RANKL) activates signaling pathways that regulate
osteoclast differentiation, function, and survival. The microphthalmia transcription factor …

The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor

NA Meadows, SM Sharma, GJ Faulkner… - Journal of biological …, 2007 - ASBMB
Microphthalmia transcription factor (MITF) regulates osteoclast function by controling the
expression of genes, including tartrate-resistant acid phosphatase (TRAP) and cathepsin K …

Mitf induction by RANKL is critical for osteoclastogenesis

SY Lu, M Li, YL Lin - Molecular biology of the cell, 2010 - Am Soc Cell Biol
Microphthalmia-associated transcription factor (Mitf) regulates the development and function
of several cell lineages, including osteoclasts. In this report, we identified a novel …

Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors

A Bronisz, SM Sharma, R Hu, J Godlewski… - Molecular biology of …, 2006 - Am Soc Cell Biol
The microphthalmia-associated transcription factor (MITF) is required for terminal osteoclast
differentiation and is a target for signaling pathways engaged by colony stimulating factor …

Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMB

VM Ripoll, NA Meadows, LJ Raggatt, MK Chang… - Gene, 2008 - Elsevier
Microphthalmia transcription factor (MITF) regulates bone homeostasis by inducing
expression of critical genes associated with osteoclast function. Gpnmb is a macrophage …

Microphthalmia transcription factor and PU. 1 synergistically induce the leukocyte receptor osteoclast-associated receptor gene expression

H So, J Rho, D Jeong, R Park, DE Fisher… - Journal of Biological …, 2003 - ASBMB
We have recently reported the identification of a novel member of the leukocyte receptor
family, osteoclast-associated receptor (OSCAR), which has two Ig-like domains and …

The microphthalmia transcription factor regulates expression of the tartrate‐resistant acid phosphatase gene during terminal differentiation of osteoclasts

A Luchin, G Purdom, K Murphy, MY Clark… - Journal of bone and …, 2000 - academic.oup.com
The defective terminal differentiation of osteoclasts in mice homozygous for the mi allele of
the microphthalmia transcription factor (MITF) gene implies that MITF plays a critical role in …

Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU. 1

M Matsumoto, M Kogawa, S Wada… - Journal of Biological …, 2004 - ASBMB
The receptor activator of NF-κB ligand (RANKL) induces various osteoclast-specific marker
genes during osteoclast differentiation mediated by mitogen-activated protein (MAP) kinase …

[HTML][HTML] Selective regulation of MAPK signaling mediates RANKL-dependent osteoclast differentiation

K Lee, YH Chung, H Ahn, H Kim, J Rho… - International Journal of …, 2016 - ncbi.nlm.nih.gov
Different stimuli often activate the same intracellular signaling molecules but trigger distinct
cell responses. We explored whether or not MAPK signaling induced by macrophage colony …

Mitf and Tfe3: members of a b-HLH-ZIP transcription factor family essential for osteoclast development and function

CL Hershey, DE Fisher - Bone, 2004 - Elsevier
The Microphthalmia-associated transcription factor (Mitf) is required for the proper
development of several cell lineages including osteoclasts, melanocytes, retinal pigment …