Granulocyte/monocyte adsorptive apheresis for the treatment of therapy-refractory chronic active ulcerative colitis

A Dignass, A Akbar, DC Baumgart… - Scandinavian journal …, 2018 - Taylor & Francis
Objectives: Current options for patients with steroid-dependent, chronic-active ulcerative
colitis (UC) with insufficient response/intolerance to immunosuppressants (ISs) and/or …

Clinical trial: five or ten cycles of granulocyte–monocyte apheresis show equivalent efficacy and safety in ulcerative colitis

AU Dignass, A Eriksson, A Kilander… - Alimentary …, 2010 - Wiley Online Library
Aliment Pharmacol Ther 31, 1286–1295 Summary Background Ulcerative colitis is
characterized by leucocyte infiltration into the colonic mucosa. Granulocyte–monocyte …

A multicenter retrospective study aiming to identify patients who respond well to adsorptive granulomonocytapheresis in moderately to severely active ulcerative colitis

T Yamamoto, T Iida, K Ikeya, M Kato… - Clinical and …, 2018 - journals.lww.com
Objectives: Adsorptive granulomonocytapheresis (GMA) with the Adacolumn has been
introduced as a nonpharmacologic treatment for ulcerative colitis (UC). However, a subset of …

[HTML][HTML] Treating inflammatory bowel disease by adsorptive leucocytapheresis: a desire to treat without drugs

AR Saniabadi, T Tanaka, T Ohmori… - World Journal of …, 2014 - ncbi.nlm.nih.gov
Ulcerative colitis and Crohn's disease are the major phenotypes of the idiopathic
inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world …

Intermittent granulocyte and monocyte apheresis versus mercaptopurine for maintaining remission of ulcerative colitis: a pilot study

A Sakuraba, T Sato, Y Morohoshi… - Therapeutic …, 2012 - Wiley Online Library
The effect of granulocyte and monocyte adsorption apheresis (GMA) on prevention of
relapse of ulcerative colitis (UC) is not clear. This was a pilot open‐labeled, prospective …

Clinical evaluation of granulocyte/monocyte apheresis therapy for active ulcerative colitis

K Kanke, M Nakano, H Hiraishi, A Terano - Digestive and liver disease, 2004 - Elsevier
BACKGROUND.: Recent evidence suggests that peripheral blood granulocytes and
monocytes/macrophages have a major role in the exacerbation of ulcerative colitis. AIMS …

Therapeutic efficacy of granulocyte and monocyte adsorption apheresis in severe active ulcerative colitis

H Hanai, F Watanabe, AR Saniabadi… - Digestive diseases …, 2002 - search.proquest.com
Ulcerative colitis (UC) is a chronic and recurrent inflammatory bowel disease that appears
with varying severity. The disease is associated with activation of the immune system and …

Adacolumn leucocytapheresis for ulcerative colitis: clinical and endoscopic features of responders and unresponders

R Sacco, T Tanaka, T Yamamoto, G Bresci… - Expert Review of …, 2015 - Taylor & Francis
Cytokines such as TNF-α have a validated role in the immunopathogensis of ulcerative
colitis (UC), and intercepting inflammatory cytokines is currently the best option for …

Adsorptive granulocyte and monocyte apheresis versus prednisolone in patients with corticosteroid-dependent moderately severe ulcerative colitis

H Hanai, F Watanabe, M Yamada, Y Sato, K Takeuchi… - Digestion, 1945 - karger.com
Background/Aim: Active ulcerative colitis (UC) is often associated with increased peripheral
granulocytes and monocytes/macrophages which show activation behavior and prolonged …

Treating ulcerative colitis by Adacolumn therapeutic leucocytapheresis: clinical efficacy and safety based on surveillance of 656 patients in 53 centres in Japan

T Hibi, Y Sameshima, Y Sekiguchi, Y Hisatome… - Digestive and Liver …, 2009 - Elsevier
BACKGROUND/AIM: The Adacolumn selectively depletes granulocytes and monocytes/
macrophages, which are thought to be part of the immunopathogenesis of ulcerative colitis …