Parkinson's disease is one of the most common neurodegenerative diseases in the elderly.
The motor symptoms occur predominantly due to substantial dopamine depletion, caused by …

Bax is a proapoptotic member of the Bcl‐2 family of proteins. It is believed to exert its action
primarily by facilitating the release of cytochrome c from the mitochondrial intermembrane …

Introduction 3. The apoptosis death machinery 3.1. Signaling via death receptors and
mitochondria 3.2. Caspases: Apoptosis initiation and execution 3.3. Mediators of cellular …

Caspase-3 is an effector of apoptosis in experimental models of Parkinson's disease (PD).
However, its potential role in the human pathology remains to be demonstrated. Using …

Caspase-8 is a proximal effector protein of the tumor necrosis factor receptor family death
pathway. In the present human postmortem study, we observed a significantly higher …

Parkinson's disease (PD) is a severe and progressive neurodegenerative disease. It is the
second most common neurodegenerative disease, after Alzheimer's disease. It is caused by …

Controversy has surrounded a role for apoptosis in the loss of neurons in Parkinson's
disease (PD). Although a variety of evidence has supported an apoptotic contribution to PD …

Recently it has been hypothesized that apoptotic cell death is involved in several
neuropathological conditions including Parkinson's disease (PD). Initial morphological …

Neurodegenerative disorders are characterized by progressive loss of particular populations
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …

ABSTRACT The Bcl-2 and Bcl-x proteins suppress programmed cell death, whereas Bax
promotes apoptosis. We investigated the pattern of expression of Bcl-2, Bax and Bcl-x during …