Background: Adiposity is a risk factor for type 2 diabetes and cardiovascular disease,
suggesting an important role for adipose tissue in the development of these conditions. The …

Background Epigenetic mechanisms provide an interface between environmental factors
and the genome and are known to play a role in complex diseases such as obesity. These …

Dysregulation of circulating lipids is a central element for the metabolic syndrome. However,
it is not well established whether human subcutaneous adipose tissue is affected by or affect …

Background Obesity is associated with changes in fat cell gene expression and metabolism.
What drives these changes is not well understood. We aimed to explore fat cell epigenetics …

Aims/hypothesis Epigenetic alterations may influence the metabolic pathways involved in
human obesity. We hypothesised that global DNA methylation levels in adipose tissue might …

Aim: To define the genomic distribution and function of DNA methylation changes during
human adipogenesis. Methods: We isolated adipocyte-derived stem cells from 13 …

Background Obesity is a well-recognized risk factor for insulin resistance and type 2
diabetes (T2D), although the precise mechanisms underlying the relationship remain …

Most epigenome-wide association studies to date have been conducted in blood. However,
metabolic syndrome is mediated by a dysregulation of adiposity and therefore it is critical to …

Objective/methods DNA methylation plays an important role in obesity and related metabolic
complications. We examined genome-wide DNA promoter methylation along with mRNA …

Background Obesity is an established risk factor for several common chronic diseases such
as breast and colorectal cancer, metabolic and cardiovascular diseases; however, the …