The objective of this study was to evaluate ten methods for calculating creatinine clearance
(Clcr) in children with renal dysfunction. The design was a prospective, comparative study …

Measurement of renal function is important to optimize drug dosing in critically ill pediatric
patients and to prevent dose-related toxicities caused by medications that are eliminated or …

Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-
lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models …

We established dose estimation formulae for renal-excretion drugs using the glomerular
filtration rate (GFR), tubular secretion clearance (Sc), and unbound fraction of drug in …

Recently, Schwartz et al.(J Am Soc Nephrol 20: 629–637, 2009) used data from the National
Institutes of Health-funded Chronic Kidney Disease in Children (CKiD) study to generate …

Background Antibiotic dosing in critically ill patients is complicated by variations in the
pharmacokinetics of antibiotics in this group. The dosing of imipenem/cilastatin is usually …

Piperacillin (PIP) is a new penicillin derivative with enhanced activity against gram-negative
organisms. We evaluated the pharmacokinetics of this compound in 13 children (ages 1.1 …

Piperacillin/tazobactam, an intravenous antibacterial combination product, has recently
been approved for paediatric (age 2 months to 17 years) use in the USA. The purpose of this …

Acute kidney injury (AKI) is a commonly encountered comorbidity in critically ill children. The
coexistence of AKI disturbs drug pharmacokinetics and pharmacodynamics, leading to …

OBJECTIVES: Evaluate if Cockcroft and Gault (CG) estimated glomerular filtration rate
(eGFR) might be replaced by abbreviated MDRD eGFR for drug dose adjustment. DESIGN …