Physiologically based pharmacokinetic (PBPK) modeling has unique advantages in
investigating the pharmacokinetics of drugs in special populations. Our aim is to design …

This study aimed to characterize the population pharmacokinetics (PKs) of piperacillin and
investigate probability of target attainment (PTA) and cumulative fraction of response (CFR) …

Background: Accurate estimation of kidney function is essential for safe administration of
renally cleared drugs. Current practice recommends adjusting renally eliminated drugs …

The primary objective of this work was to characterize the pharmacokinetics (PK) of
gentamicin across the whole pediatric age spectrum from premature neonates to young …

Critically ill patients undergo significant pathophysiological changes that affect antibiotic
pharmacokinetics. Piperacillin/tazobactam administered by continuous infusion (CI) …

Sufficient antibiotic dosing in septic patients is essential for reducing mortality. Piperacillin-
tazobactam is often used for empirical treatment, but due to the pharmacokinetic (PK) …

Background Equations for the creatinine-based estimated glomerular filtration rate (eGFR)
were recently established for Japanese adults (> 18 years old) and children (2–11 years …

The abilities of a modified Cockcroft-Gault equation and the standard equation to estimate
creatinine clearance (CLcr) in trauma patients were compared. The medical records of …

Iohexol clearance is an accepted, but time-consuming assay for the measurement of
glomerular filtration rate (GFR). We investigated if simpler methods could predict GFR. Sixty …

Background Acute kidney injury (AKI) and augmented renal clearance (ARC), both
alterations of the glomerular filtration rate (GFR), are prevalent in critically ill children and …