Background In the present study we determined the antihyperalgesic and antiallodynic effect
of celecoxib in diabetic rats as well as the possible participation of opioid receptors in the …

ABSTRACT Preclinical Research The aim of the present study was to analyze the
antihyperalgesic and antiallodynic interaction between the non‐selective cholecystokinin …

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits
cyclooxygenase-2 (COX-2). Like most NSAIDs, celecoxib exhibits analgesic effects in …

The non-steroidal anti-inflammatory drug celecoxib has long been used for reducing pain, in
spite of moderate gastrointestinal side effects. In previous studies, it has been shown that …

Background Celecoxib exerted analgesic effects (hypoalgesia) reversed by opioid receptor
antagonists in a model of inflammatory pain. To analyze this celecoxib-induced hypoalgesia …

Background and objectives: The clinical use of non-steroidal anti-inflammatory drugs is
limited due to high incidence of adverse drug reactions. The pyrrole heterocycle is included …

AIMS: The endogenous opioids mediate the analgesic effects of celecoxib in a model of
mechanical hyperalgesia in rats. As responses to thermal stimuli may differ from those to …

In a model of peripherally induced inflammatory pain in rats, selective inhibitors of
cyclooxygenase (COX)-2 raised nociceptive thresholds above basal values, an effect …

Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) and blocks prostaglandin
(PG) biosynthesis associated with inflammatory conditions. In a model of peripherally …

We previously reported that OT-7100 (5-n-butyl-7-(3, 4, 5-trimethoxybenzoylamino) pyrazolo
[1, 5-α] pyrimidine) had antinociceptive potency in various animal models. To further …