Diabetic neuropathy is recognized as one of the most common complications of chronic
diabetes, but its pathophysiological mechanism is complex and yet to be completely …

Background: Cilostazol is an antiplatelet agent with vasodilating, endothelial function
restoration, and anti-inflammatory effects. This study aims to investigate the efficacy of oral …

Neuropathic pain in diabetics is characterized by both hyperalgesia and allodynia. This is
attributed to both uncontrolled glycemia and the further complications which it leads to. We …

Mechanical allodynia is a major complication in diabetic mellitus. Peripheral σ1 receptors
were shown to be involved in nociceptive perception. We therefore investigated the effect of …

Only a few experimental studies have demonstrated the effectiveness of some
cyclooxygenase-2 (COX-2) inhibitors for neuropathic pain in diabetic animals. In this study …

Mechanical allodynia, which develops in patients of diabetes mellitus as a neuropathic
manifestation, remains without an effective treatment. The aim of the present study was to …

Diabetic neuropathic pain, an important microvascular complication of diabetes mellitus is
recognized as one of the most difficult types of pain to treat. The development of tolerance …

OBJECTIVE—Diabetic neuropathy is manifested either by loss of nociception (painless
syndrome) or by mechanical hyperalgesia and tactile allodynia (pain in response to …

We examined a possible involvement of cyclooxygenase (COX) and nitric oxide synthase
(NOS) products in hyperalgesia occurring during streptozotocin (STZ)-induced diabetes …

The purpose of this study was to assess the antinociceptive and antiallodynic effect of
pyritinol as well as its possible mechanism of action in diabetic rats. Streptozotocin (50 …