Background/Aims: Gentiopicroside is promising as an important secoiridoid compound
against pain. The present study aimed to investigate the analgesic effect and the probable …

ABSTRACT Preclinical Research Metformin‐dependent mechanisms have been implicated
in the antinociceptive effect of some non‐steroidal anti‐inflammatory drugs (NSAIDs). In this …

Background Osteoarthritis (OA) is the most common joint disease, especially affecting the
knee joint. Etoricoxib, a highly selective cyclooxygenase (COX)‐2 inhibitor which can reduce …

ABSTRACT Celecoxib, a selective cyclooxygenase‐2 (COX‐2) inhibitor, has recently been
approved for the symptomatic treatment of arthritis. In some clinical studies, doses of 400 …

We evaluated the effects of zonisamide on inflammatory and neuropathic pain using the
mouse formalin test and streptozotocin (STZ)-induced diabetic mice with a reduced …

Non-steroidal antiinflammatory drugs (NSAIDs) are known to induce analgesia mainly via
inhibition of cyclooxygenase (COX). Although the inhibition of COX in the periphery is …

The present study was designed to investigate the effect of cyclosporine on hyperglycemia
induced decrease antinociceptive effect of morphine in rats. Streptozotocin (STZ)(50 mg kg" …

The duration of the somatostatin-, bradykinin-or prostaglandin F2α-induced nociceptive
response was significantly less in diabetic mice than in non-diabetic mice. Subcutaneous …

Background: The analgesic effects of celecoxib, a cyclooxygenase‐2 (COX‐2) inhibitor, on
formalin‐induced pain are still controversial. The purpose of this study was to examine the …

Objective (s): Celecoxib (CLX), a selective cyclooxygenase-II (COX-2) inhibitor, has been
used for management of several inflammatory disorders. The present study aimed to explore …