Cleft lip with or without cleft palate is the most common facial birth defect and it is caused by
a complex interaction between genetic and environmental factors. The purpose of this …

Orofacial clefts are common birth defects and can occur as isolated, nonsyndromic events or
as part of Mendelian syndromes. There is substantial phenotypic diversity in individuals with …

Orofacial clefts (cleft lip, cleft palate) are among the most common of all major birth defects,
but very little is known about their causation. Genetic factors are thought to play a major role …

Objective. To review recent data on the aetiology of cleft lip and palate. Data sources.
MEDLINE literature search (1986-2003). Study selection. Literature and data on aetiology of …

Orofacial clefts include cleft lip (CL), cleft palate (CP), and cleft lip and palate (CLP), which
combined represent the largest group of craniofacial malformations in humans with an …

Orofacial clefts (OFCs)—primarily cleft lip and cleft palate—are among the most common
birth defects in all populations worldwide, and have notable population, ethnicity, and …

Clefts of the lip and/or palate (CL/P) are among the most common birth defects worldwide.
The majority are non-syndromic where CL/P occurs in isolation of other phenotypes. Where …

Cleft lip and palate are common congenital anomalies with significant medical,
psychological, social, and economic ramifications, affecting one in seven hundred live births …

Nonsyndromic orofacial clefts have a multifactorial etiology, involving both genetic and
environmental factors. Although linkage and candidate gene studies have attempted to …

Orofacial clefts (OFCs) are common, complex birth defects with extremely heterogeneous
phenotypic presentations. Two common subtypes—cleft lip alone (CL) and CL plus cleft …