Genetic causes of nonsyndromic cleft lip with or without cleft palate

Q Yuan, SH Blanton, JT Hecht - … Genetics in the Clinical Practice of …, 2011 - karger.com
Nonsyndromic cleft lip with or without an associated cleft palate (NSCLP) is one of the most
common birth defects affecting 135,000 babies worldwide each year. It causes severe facial …

Orofacial clefts embryology, classification, epidemiology, and genetics

G Nasreddine, J El Hajj… - … Research/Reviews in …, 2021 - Elsevier
Orofacial clefts (OFCs) rank as the second most common congenital birth defect in the
United States after Down syndrome and are the most common head and neck congenital …

Identifying genetic sources of phenotypic heterogeneity in orofacial clefts by targeted sequencing

JC Carlson, MA Taub, E Feingold, TH Beaty… - Birth defects …, 2017 - Wiley Online Library
Background Orofacial clefts (OFCs), including nonsyndromic cleft lip with or without cleft
palate (NSCL/P), are common birth defects. NSCL/P is highly heterogeneous with multiple …

The complex genetics of cleft lip and palate

MT Cobourne - The European Journal of Orthodontics, 2004 - academic.oup.com
Clefts of the lip and palate are a common craniofacial anomaly, requiring complex
multidisciplinary treatment and having lifelong implications for affected individuals. The …

The current understanding of cleft lip malformations

N Wantia, G Rettinger - Facial plastic surgery, 2002 - thieme-connect.com
Cleft lip with or without cleft palate is one of the most common congenital malformations.
Epidemiology differentiates between cleft malformations connected with syndromes and the …

The many faces and factors of orofacial clefts

BC Schutte, JC Murray - Human molecular genetics, 1999 - academic.oup.com
Orofacial clefts are congenital structural anomalies of the lip and/or palate that affect∼
1/1000 live births. Their frequent occurrence as well as their extensive psychological …

Genome scan, fine-mapping, and candidate gene analysis of non-syndromic cleft lip with or without cleft palate reveals phenotype-specific differences in linkage and …

ML Marazita, AC Lidral, JC Murray, LL Field… - Human …, 2009 - karger.com
Objectives: Non-syndromic orofacial clefts, ie cleft lip (CL) and cleft palate (CP), are among
the most common birth defects. The goal of this study was to identify genomic regions and …

Genetic models and approaches to study orofacial clefts

EJ Leslie - Oral diseases, 2022 - Wiley Online Library
Abstract Introduction Orofacial clefts (OFCs) are common craniofacial birth defects with
heterogeneous phenotype and etiology. Geneticists have applied nearly every available …

Incidence and aetiology of oral clefts: a review

HO Olasoji, OE Ukiri, A Yahaya - 2005 - adhlui.com.ui.edu.ng
Craniofacial anomalies, most especially cleft lip and pal ate, arc major human birth
deformities with a world wide incidence of 1 in 700 and associated substantial clinical and …

[HTML][HTML] Epidemiology of cleft lip and palate

MK Ahmed, AH Bui, E Taioli - Designing strategies for cleft lip and …, 2017 - intechopen.com
Orofacial cleft (OFC) anomalies are amongst the most common congenital anomalies and
the most common craniofacial anomalies. Despite their poorly characterized etiologies …