Background: The systemic manifestations of acute pancreatitis are responsible for the
majority of pancreatitis-associated morbidity and mortality and are now believed to be due to …

The local, noninfectious inflammation of the pancreas during acute pancreatitis (AP) may
evolve into a systemic inflammatory disease involving other organs, particularly the lungs …

Our purpose was to determine if cytokines are produced systemically during acute
pancreatitis. Proinflammatory cytokines are elevated during acute pancreatitis and have …

Abstract Development of acute pancreatitis illustrates the need to understand the basic
mechanisms of disease progression to drive the exploration of therapeutic options …

Objectives We aimed at synchronously examining the early time course of 4 proinflammatory
cytokines as predictive factors for development of organ failure in patients with acute …

Acute pancreatitis is a disease with considerable lethality for which there is no specific
therapy beyond supportive treatment. Epidemiological data on the disease are sparse, but …

in propagation of pancreatitis, cytokines are incapable of initiating pancreatitis, as we have
shown in the perfused human pancreas. Nevertheless, cytokines can induce apoptosis in …

Efforts to unravel the events in the evolution of tissue damage in acute pancreatitis have
shown a number of inflammatory mediators to be involved. The pathways of damage are …

Inflammatory mediators play a key role in acute pancreatitis and the resultant multiple organ
dysfunction syndrome, which is the primary cause of death in this condition. Recent studies …

Cytokines have been shown to play a pivotal role in multiple organ dysfunction, a major
cause of death in severe acute pancreatitis. Moreover, the two-hit hypothesis of the cytokine …