African trypanosomiasis-associated anemia: the contribution of the interplay between parasites and the mononuclear phagocyte system
B Stijlemans, P De Baetselier, S Magez… - Frontiers in …, 2018 - frontiersin.org
African trypanosomosis (AT) is a chronically debilitating parasitic disease of medical and
economic importance for the development of sub-Saharan Africa. The trypanosomes that …
economic importance for the development of sub-Saharan Africa. The trypanosomes that …
The central role of macrophages in trypanosomiasis-associated anemia: rationale for therapeutical approaches
B Stijlemans, A Vankrunkelsven… - … Metabolic & Immune …, 2010 - ingentaconnect.com
Bovine African trypanosomiasis causes severe economical problems on the African
continent and one of the most prominent immunopathological parameters associated with …
continent and one of the most prominent immunopathological parameters associated with …
African trypanosomosis: from immune escape and immunopathology to immune intervention
African trypanosomes can cause prolonged chronic infections through a mechanism of
antigen variation whereby they manipulate the humoral immune system of their hosts …
antigen variation whereby they manipulate the humoral immune system of their hosts …
Iron Homeostasis and Trypanosoma brucei Associated Immunopathogenicity Development: A Battle/Quest for Iron
B Stijlemans, A Beschin, S Magez… - BioMed Research …, 2015 - Wiley Online Library
African trypanosomosis is a chronic debilitating disease affecting the health and economic
well‐being of developing countries. The immune response during African trypanosome …
well‐being of developing countries. The immune response during African trypanosome …
Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P
T Bosschaerts, M Guilliams, W Noel… - The Journal of …, 2008 - journals.aai.org
Uncontrolled inflammation is a major cause of tissue injury/pathogenicity often resulting in
death of a host infected with African trypanosomes. Thus, comparing the immune response …
death of a host infected with African trypanosomes. Thus, comparing the immune response …
Understanding the role of monocytic cells in liver inflammation using parasite infection as a model
T Bosschaerts, M Guilliams, B Stijlemans… - Immunobiology, 2009 - Elsevier
Uncontrolled inflammation is a major cause of pathogenicity during chronic parasite
infections. Novel therapies should therefore aim at re-establishing the balance between pro …
infections. Novel therapies should therefore aim at re-establishing the balance between pro …
Role of iron homeostasis in trypanosomiasis-associated anemia
B Stijlemans, A Vankrunkelsven, L Brys, S Magez… - Immunobiology, 2008 - Elsevier
Anemia is a well-established infection-associated immunopathological feature of
trypanosomiasis and the degree of the anemia is a reliable indicator of the severity of …
trypanosomiasis and the degree of the anemia is a reliable indicator of the severity of …
African trypanosomes undermine humoral responses and vaccine development: link with inflammatory responses?
B Stijlemans, M Radwanska, C De Trez… - Frontiers in …, 2017 - frontiersin.org
African trypanosomosis is a debilitating disease of great medical and socioeconomical
importance. It is caused by strictly extracellular protozoan parasites capable of infecting all …
importance. It is caused by strictly extracellular protozoan parasites capable of infecting all …
NK-, NKT-and CD8-derived IFNγ drives myeloid cell activation and erythrophagocytosis, resulting in trypanosomosis-associated acute anemia
J Cnops, C De Trez, B Stijlemans, J Keirsse… - PLoS …, 2015 - journals.plos.org
African trypanosomes are the causative agents of Human African Trypanosomosis
(HAT/Sleeping Sickness) and Animal African Trypanosomosis (AAT/Nagana). A common …
(HAT/Sleeping Sickness) and Animal African Trypanosomosis (AAT/Nagana). A common …
Experimental expansion of the regulatory T cell population increases resistance to African trypanosomiasis
M Guilliams, T Bosschaerts, M Hérin… - The Journal of …, 2008 - academic.oup.com
Inflammatory responses mounted to eliminate parasites can be lethal if not counterbalanced
by regulatory responses protecting the host from collateral tissue damage. Here, we show …
by regulatory responses protecting the host from collateral tissue damage. Here, we show …