Interferons (IFNs) and inflammasomes are essential mediators of anti-microbial immunity.
Type I IFN signaling drives activation of the AIM2 inflammasome in macrophages; however …

Inflammasomes are critical for mounting host defense against pathogens. The molecular
mechanisms that control activation of the AIM2 inflammasome in response to different …

The inflammasome is a signaling platform that is central to the innate immune responses to
bacterial infections. Francisella tularensis is a bacterium replicating within the host cytosol …

Francisella tularensis is a pathogenic bacterium whose virulence is linked to its ability to
replicate within the host cell cytosol. Entry into the macrophage cytosol activates a host …

The AIM2 inflammasome detects double-stranded DNA in the cytosol and induces caspase-
1-dependent pyroptosis as well as release of the inflammatory cytokines interleukin 1β (IL …

The intracellular bacterium Francisella tularensis is the causative agent of tularemia, a
potentially fatal disease. In macrophages, Francisella escapes the initial phagosome and …

Activation of the inflammasome is important for the detection and clearance of cytosolic
pathogens. In contrast to avirulent Francisella novicida (Fn), infection with virulent …

Macrophages respond to cytosolic nucleic acids by activating cysteine protease caspase-1
within a complex called the inflammasome. Subsequent cleavage and secretion of …

Guanylate binding proteins (GBPs) are interferon-inducible proteins involved in the cell-
intrinsic immunity against numerous intracellular pathogens. The molecular mechanisms …

Intracellular bacterial pathogens Francisella novicida and the Live Vaccine Strain (LVS) are
recognized in the macrophage cytosol by the AIM2 inflammasome, which leads to the …