Many epigenetic association studies have attempted to identify DNA methylation markers in
blood that are able to mirror those in target tissues. Although some have suggested potential …

Most epigenome-wide association studies to date have been conducted in blood. However,
metabolic syndrome is mediated by a dysregulation of adiposity and therefore it is critical to …

Epigenetic modifications such as DNA methylation play a key role in gene regulation and
disease susceptibility. However, little is known about the genome-wide frequency …

Background Elevated adiposity is often posited by medical and public health researchers to
be a risk factor associated with cardiovascular disease, diabetes, and other diseases. These …

Background Epigenetic mechanisms provide an interface between environmental factors
and the genome and are known to play a role in complex diseases such as obesity. These …

Epigenetic variation in human adipose tissue has been linked to type 2 diabetes and its
related risk factors including age and obesity. Insulin resistance, a key risk factor for type 2 …

Obesity is directly connected to lifestyle and has been associated with DNA methylation
changes that may cause alterations in the adipogenesis and lipid storage processes …

Epigenetic mechanisms are implicated in gene regulation and the development of different
diseases. The epigenome differs between cell types and has until now only been …

Increased age, BMI and HbA1c levels are risk factors for several non-communicable
diseases. However, the impact of these factors on the genome-wide DNA methylation …

DNA methylation variations are prevalent in human obesity but evidence of a causative role
in disease pathogenesis is limited. Here, we combine epigenome-wide association and …