Psoriasis is a common autoimmune skin disease characterized by T cell-mediated
hyperproliferation of keratinocytes. The disease has a strong but complex genetic …

We investigated the HLA-C locus of 87 unrelated patients with chronic plaque psoriasis by
genotyping with sequence-specifc amplification printers. The HLA-Cw* 0602 allele was …

The analysis of population-specific human leukocyte antigen (HLA) haplotypes has provided
evidence that susceptibility to psoriasis is linked to the class I and II major histocompatibility …

In various immunological disorders the pathomechanisms of tissue damage are causally
associated with specific patterns of locally produced cytokines. To study the molecular and …

Recent studies have provided new insights into the molecular mechanisms involved in the
pathogenesis of psoriasis. Patients may inherit a predisposition to psoriasis, although the …

Although the pathogenesis of psoriasis is still a matter of debate, there are several lines of
evidence supporting the concept of this disease being immunologically mediated with T …

Non-pustular psoriasis consists of two disease subtypes, type I and type II, which
demonstrate distinct characteristics. Firstly the disease presents in different decades of life …

In the last few years, molecular genetics analyses have permitted novel insights into
psoriasis, a disease characterized by uncontrolled proliferation of keratinocytes and …

Psoriasis is characterized by sustained T cell activation by antigen-presenting cells (APCs)
in the lesions, and by a deviation of T cell differentiation to type 1 helper T and type 1 …

Evidence for a key role of T cells in the pathogenesis of psoriasis has come from both
experimental and clinical data. Initially, generalized immunosuppressants, intended for use …