Neglected tropical diseases (NTDs), which include leishmaniasis, Chagas disease, human
African trypanosomiasis (HAT), and schistosomiasis, remain public health problems in …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

Leishmaniasis (Leishmania species), sleeping sickness (Trypanosoma brucei), and Chagas
disease (Trypanosoma cruzi) are devastating and globally spread diseases caused by …

Open-access drug discovery provides a substantial resource for diseases primarily affecting
the poor and disadvantaged. The open-access Pathogen Box collection is comprised of …

Background The increased sequencing of pathogen genomes and the subsequent
availability of genome-scale functional datasets are expected to guide the experimental …

Diseases caused by tropical parasites affect hundreds of millions of people worldwide but
have been largely neglected for drug development because they affect poor people in poor …

“We have never had such a sophisticated arsenal of technologies for treating diseases, yet
the gap in health outcomes keep getting wider. This is unacceptable.” This claim was made …

Neglected tropical diseases (NTDs) refer to a group of infectious diseases, which though
treatable and/or preventable, remain a leading cause of morbidity and mortality among the …

Phenotypic screening had successfully been used for hit generation, especially in the field of
neglected diseases, in which feeding the drug pipeline with new chemotypes remains a …

The protozoan diseases Human African Trypanosomiasis (HAT), Chagas disease (CD), and
leishmaniases span worldwide and therefore their impact is a universal concern. The …