The study of experimental colon carcinogenesis in rodents has a long history, dating back
almost 80 years. There are many advantages to studying the pathogenesis of carcinogen …

Colorectal cancer is a heterogeneous disease that afflicts a large number of people in the
USA. The use of animal models has the potential to increase our understanding of …

Colorectal cancer (CRC) is the third most common diagnosed malignancy among both
sexes in the United States as well as in the European Union. While the incidence and …

In this review, we discuss the application of mouse models to the identification and pre‐
clinical validation of novel therapeutic targets in colorectal cancer, and to the search for early …

This review gives a comprehensive overview of cancer development and links it to the
current understanding of tumorigenesis and malignant progression in colorectal cancer. The …

Mutations in the adenomatous polyposis coli (APC) gene are pivotal in colorectal
tumorigenesis. Existing mouse intestinal tumor models display mainly small intestinal …

The marked diversity in the phenotype of intestinal neoplasia in murine models offers
opportunities to model many characteristics of human CRC, including tumor progression …

Studies of colon carcinogenesis in animal models are very useful to elucidate mechanisms
and provide pointers to potential prevention approaches in the human situation. In the rat …

Most genetically engineered mouse (GEM) models for colon cancer are based on
tissuewide or germline gene modification, resulting in tumors predominantly of the small …

Tumours in rodent and human colon share many histological and genetic features. To know
if rodent models of colon carcinogenesis are good predictors of chemopreventive efficacy in …