Host genetic and environmental effects on mouse intestinal microbiota

JH Campbell, CM Foster, T Vishnivetskaya… - The ISME …, 2012 - academic.oup.com
The mammalian gut harbors complex and variable microbial communities, across both host
phylogenetic space and conspecific individuals. A synergy of host genetic and …

Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors

AK Benson, SA Kelly, R Legge, F Ma… - Proceedings of the …, 2010 - National Acad Sciences
In vertebrates, including humans, individuals harbor gut microbial communities whose
species composition and relative proportions of dominant microbial groups are …

Host genetic determinants of the gut microbiota of wild mice

TA Suzuki, M Phifer‐Rixey, KL Mack… - Molecular …, 2019 - Wiley Online Library
Identifying a common set of genes that mediate host–microbial interactions across
populations and species of mammals has broad relevance for human health and animal …

[HTML][HTML] Variation in taxonomic composition of the fecal microbiota in an inbred mouse strain across individuals and time

YE Hoy, EM Bik, TD Lawley, SP Holmes, DM Monack… - PloS one, 2015 - journals.plos.org
Genetics, diet, and other environmental exposures are thought to be major factors in the
development and composition of the intestinal microbiota of animals. However, the relative …

Murine genetic background has a stronger impact on the composition of the gut microbiota than maternal inoculation or exposure to unlike exogenous microbiota

H Korach-Rechtman, S Freilich… - Applied and …, 2019 - Am Soc Microbiol
The gut microbiota is a complex ecosystem, affected by both environmental factors and host
genetics. Here, we aim at uncovering the bacterial taxa whose gut persistence is controlled …

[HTML][HTML] Effects of vendor and genetic background on the composition of the fecal microbiota of inbred mice

AC Ericsson, JW Davis, W Spollen, N Bivens, S Givan… - PloS one, 2015 - journals.plos.org
The commensal gut microbiota has been implicated as a determinant in several human
diseases and conditions. There is mounting evidence that the gut microbiota of laboratory …

The role of biogeography in shaping diversity of the intestinal microbiota in house mice

M Linnenbrink, J Wang, EA Hardouin… - Molecular …, 2013 - Wiley Online Library
The microbial communities inhabiting the mammalian intestinal tract play an important role
in diverse aspects of host biology. However, little is known regarding the forces shaping …

[HTML][HTML] The Mouse Intestinal Bacterial Collection (miBC) provides host-specific insight into cultured diversity and functional potential of the gut microbiota

I Lagkouvardos, R Pukall, B Abt, BU Foesel… - Nature …, 2016 - nature.com
Intestinal bacteria influence mammalian physiology, but many types of bacteria are still
uncharacterized. Moreover, reference strains of mouse gut bacteria are not easily available …

Impact of host genetics on gut microbiome: Take‐home lessons from human and mouse studies

I Cahana, FA Iraqi - Animal models and experimental medicine, 2020 - Wiley Online Library
The intestinal microbiome has emerged as an important component involved in various
diseases. Therefore, the interest in understanding the factors shaping its composition is …

[HTML][HTML] Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice

F Hildebrand, TLA Nguyen, B Brinkman, RG Yunta… - Genome biology, 2013 - Springer
Background Murine models are a crucial component of gut microbiome research.
Unfortunately, a multitude of genetic backgrounds and experimental setups, together with …