[HTML][HTML] Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis
Background Multiple sclerosis (MS), an autoimmune disease of the central nervous system
(CNS), can be suppressed in its early stages but eventually becomes clinically progressive …
(CNS), can be suppressed in its early stages but eventually becomes clinically progressive …
[HTML][HTML] Monocytes and monocyte-derived antigen-presenting cells have distinct gene signatures in experimental model of multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disease mediated by a complex interaction
between the autoreactive lymphocytes and the effector myeloid cells within the central …
between the autoreactive lymphocytes and the effector myeloid cells within the central …
Mass cytometry of CSF identifies an MS-associated B-cell population
D Johansson, C Rauld, J Roux… - Neurology …, 2021 - AAN Enterprises
Objective To identify an MS-specific immune cell population by deep immune phenotyping
and relate it to soluble signaling molecules in CSF. Methods We analyzed surface …
and relate it to soluble signaling molecules in CSF. Methods We analyzed surface …
[HTML][HTML] Expansion of neutrophils and classical and nonclassical monocytes as a hallmark in relapsing-remitting multiple sclerosis
D Haschka, P Tymoszuk, G Bsteh, V Petzer… - Frontiers in …, 2020 - frontiersin.org
Neutrophils and monocytes encompassing the classical, intermediate, and nonclassical
population constitute the majority of circulating myeloid cells in humans and represent the …
population constitute the majority of circulating myeloid cells in humans and represent the …
Multiple sclerosis endophenotypes identified by high-dimensional blood signatures are associated with distinct disease trajectories
CC Gross, A Schulte-Mecklenbeck… - Science Translational …, 2024 - science.org
One of the biggest challenges in managing multiple sclerosis is the heterogeneity of clinical
manifestations and progression trajectories. It still remains to be elucidated whether this …
manifestations and progression trajectories. It still remains to be elucidated whether this …
[HTML][HTML] Bone marrow hematopoiesis drives multiple sclerosis progression
K Shi, H Li, T Chang, W He, Y Kong, C Qi, R Li… - Cell, 2022 - cell.com
Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous
system (CNS). Bone marrow hematopoietic stem and progenitor cells (HSPCs) rapidly …
system (CNS). Bone marrow hematopoietic stem and progenitor cells (HSPCs) rapidly …
Monocytes in multiple sclerosis: phenotype and cytokine profile
M Kouwenhoven, N Teleshova, V Özenci… - Journal of …, 2001 - Elsevier
Multiple sclerosis (MS) is an inflammatory demyelinating disease characterised by immune
abnormalities in the central nervous system (CNS) as well as systemically. Activated, blood …
abnormalities in the central nervous system (CNS) as well as systemically. Activated, blood …
Subsets of activated monocytes and markers of inflammation in incipient and progressed multiple sclerosis
MC Gjelstrup, M Stilund, T Petersen… - Immunology and cell …, 2018 - Wiley Online Library
Multiple sclerosis (MS) is an immune mediated, inflammatory and demyelinating disease of
the central nervous system (CNS). Substantial evidence points toward monocytes and …
the central nervous system (CNS). Substantial evidence points toward monocytes and …
[HTML][HTML] Regulatory cells in multiple sclerosis: From blood to brain
Multiple sclerosis (MS) is a chronic, autoimmune, and neurodegenerative disease of the
central nervous system (CNS) that affects myelin. The etiology of MS is unclear, although a …
central nervous system (CNS) that affects myelin. The etiology of MS is unclear, although a …
Expanded CD 8 T‐cell sharing between periphery and CNS in multiple sclerosis
M Salou, A Garcia, L Michel… - Annals of clinical …, 2015 - Wiley Online Library
Objective In multiple sclerosis (MS), central nervous system (CNS), cerebrospinal fluid
(CSF), and blood display TCR clonal expansions of CD 8+ T cells. These clones have been …
(CSF), and blood display TCR clonal expansions of CD 8+ T cells. These clones have been …