Objective In multiple sclerosis (MS), central nervous system (CNS), cerebrospinal fluid
(CSF), and blood display TCR clonal expansions of CD 8+ T cells. These clones have been …

The advent of highly effective disease modifying therapy has transformed the landscape of
multiple sclerosis (MS) care over the last two decades. However, there remains a critical …

INTRODUCTION Under homeostasis, the central nervous system (CNS) hosts microglia
(MG) and CNS-associated macrophages (CAMs). During experimental autoimmune …

Background A subset of T-cells expresses the B-cell marker CD20 and in rheumatoid
arthritis secretes Interleukin (IL)-17. IL-17 secreting T-cells (Th17) have also been implicated …

Multiple sclerosis is a chronic inflammatory and demyelinating disease of the CNS with, as
yet, an unknown aetiology. Temporal profile, intensity and treatment responses are highly …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) characterized by destruction of the myelin sheath structure. The loss of myelin leads …

Background Emerging RNA viruses that target the central nervous system (CNS) lead to
cognitive sequelae in survivors. Studies in humans and mice infected with West Nile virus …

Multiple sclerosis (MS) is the leading cause of chronic neurological disability in young
adults. The clinical disease course of MS varies greatly between individuals, with some …

Novel insights from basic and translational studies are reshaping concepts of the
immunopathogenesis of multiple sclerosis and understanding of the different inflammatory …

Multiple sclerosis is an inflammatory demyelinating disease in which active demyelination
and neurodegeneration are associated with lymphocyte infiltrates in the brain. However, so …