Clinical trial results of peripheral B cell depletion indicate abnormal proinflammatory B cell
properties, and particularly antibody-independent functions, contribute to relapsing MS …

Reliable, and easy to measure, immunological markers able to denote disease
characteristics in multiple sclerosis (MS) patients are still lacking. We applied a multivariate …

In the majority of patients multiple sclerosis starts with a relapsing remitting course (RRMS),
which may at later times transform into secondary progressive disease (SPMS). In a minority …

Multiple sclerosis (MS) is a complex disease of the central nervous system (CNS), which is
believed to be immune-mediated. While CD4+ T cells have been the main suspects for …

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
characterized by focal demyelination patches associated with inflammatory infiltrates …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) with the majority of cases characterised by relapsing/remitting (RRMS) attacks …

Systemic sclerosis (SSc), systemic lupus erythematosus (SLE) and primary Sjögrens
syndrome (pSS) are clinically distinct systemic autoimmune diseases (SADs) that share …

Historically, multiple sclerosis (MS) has been viewed as being primarily driven by T cells.
However, the effective use of anti-CD20 treatment now also reveals an important role for B …

Abstract Background Systemic sclerosis (SSc) is a genetically complex autoimmune disease
mediated by the interplay between genetic and epigenetic factors in a multitude of immune …

Molecular interventions that limit pathogenic CNS inflammation are used to treat
autoimmune conditions such as multiple sclerosis (MS). Remarkably, IL-1β–knockout mice …