The antigen-specific activation of pathogenic T cells is considered essential in the initiation
and maintenance of multiple sclerosis (MS). The site of activation, the differential …

Multiple sclerosis (MS) is the prototypical inflammatory disease of the central nervous
system (CNS). MS lesions harbor different immune cells, but the contribution of individual …

Background Multiple sclerosis (MS) is an autoimmune, neuroinflammatory disease, with an
unclear etiology. However, T cells play a central role in the pathogenesis by crossing the …

Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system,
usually occurring in young adults and leading to disability. Despite the progress in …

Effective biomarkers for multiple sclerosis diagnosis, assessment of prognosis, and
treatment responses, in particular those measurable in blood, are largely lacking. We have …

Background T cells play a key role in the pathogenesis of multiple sclerosis (MS), a chronic,
inflammatory, demyelinating disease of the central nervous system (CNS). Although several …

Multiple sclerosis, the most common cause of neurological disability in young population
after trauma, represents a significant public health burden. Current challenges associated …

Our incomplete understanding of the causes and pathways involved in the onset and
progression of multiple sclerosis (MS) limits our ability to effectively treat this complex …

Multiple sclerosis (MS) is one of the most common neurological disorders in young adults.
The etiology of MS is not known but it is widely accepted that it is autoimmune in nature …

Dimethyl fumarate (DMF) is an immunomodulatory treatment for multiple sclerosis (MS).
Despite its wide clinical use, the mechanisms underlying clinical response are not …