The molecular basis for heparin-induced thrombocytopenia (HIT), a relatively common
complication of heparin therapy, is not yet fully understood. We found that pretreatment of …

It has long been recognized that certain clinical conditions such as pregnancy, malignancy,
trauma, surgery, immobility, nephrotic syndrome, and many other situations are associated …

Purpose: We reported a 61% morbidity rate and a 23% mortality rate for the heparin-induced
thrombocytopenia (HIT) syndrome in 1983. We subsequently reported in 1987 that with early …

Pronounced hemostatic changes occur during pregnancy, and the balance shifts markedly
in favor of hypercoagulability. Although primarily a result of a marked rise in the levels of …

Heparin-induced thrombocytopenia (HIT) is an important complication of heparin therapy.
Although there is general agreement that platelet activation in vitro by the HIT IgG is …

Despite the fact that the relationship between platelets and the inflammatory and immune
responses has been reviewed previously, the allocation of platelets among the inflammatory …

The antiphospholipid syndrome is characterized by antibodies directed against
phospholipid-binding proteins and phospholipids attached to cell membrane receptors …

Background: Heparin‐induced thrombocytopenia (HIT) is a severe complication of heparin
therapy that can be associated with arterial or venous thrombosis and is caused by …

Antibodies to PF4/heparin can be demonstrated in almost all patients with heparin-induced
thrombocytopenia/thrombosis (HIT/HITT) and in some persons exposed to heparin who do …

Rapid laboratory assessment of heparin-induced thrombocytopenia (HIT) is important for
disease recognition and management. The utility of contemporary immunoassays to detect …