Design, synthesis and molecular modeling of new quinazolin-4 (3H)-one based VEGFR-2 kinase inhibitors for potential anticancer evaluation
AE Abdallah, SI Eissa, MMS Al Ward, RR Mabrouk… - Bioorganic …, 2021 - Elsevier
Globally cancer is the second leading cause of death. So that this work is an attempt to
develop new effective anti-cancer agents. In line with pharmacophoric features of VEGFR-2 …
develop new effective anti-cancer agents. In line with pharmacophoric features of VEGFR-2 …
Design, synthesis, molecular modeling, in vivo studies and anticancer evaluation of quinazolin-4 (3H)-one derivatives as potential VEGFR-2 inhibitors and apoptosis …
HA Mahdy, MK Ibrahim, AM Metwaly, A Belal… - Bioorganic …, 2020 - Elsevier
Inhibiting VEGFR-2 has been set up as a therapeutic strategy for treatment of cancer.
Accordingly, new quinazoline-based derivatives having the structural features of VEGFR-2 …
Accordingly, new quinazoline-based derivatives having the structural features of VEGFR-2 …
Design, molecular docking, in vitro, and in vivo studies of new quinazolin-4 (3H)-ones as VEGFR-2 inhibitors with potential activity against hepatocellular carcinoma
A series of new VEGFR-2 inhibitors were designed, synthesized and evaluated for their anti-
proliferative activities against hepatocellular carcinoma (HepG-2 cell line). Compound 29 b …
proliferative activities against hepatocellular carcinoma (HepG-2 cell line). Compound 29 b …
Design, synthesis, in vitro antiproliferative evaluation and in silico studies of new VEGFR-2 inhibitors based on 4-piperazinylquinolin-2 (1H)-one scaffold
Angiogenesis is essential in the growth of solid tumors which need oxygen and nutrients
supply to grow in size. The VEGF/VEGFR-2 signaling pathway plays an important role in …
supply to grow in size. The VEGF/VEGFR-2 signaling pathway plays an important role in …
Design, synthesis, in silico and antiproliferative evaluation of novel pyrazole derivatives as VEGFR‐2 inhibitors
P Ravula, HB Vamaraju, M Paturi… - Archiv der …, 2018 - Wiley Online Library
As the blockade of the VEGFR‐2 signaling pathway is a viable approach in cancer therapy,
the present study focuses on a series of pyrazole based VEGFR‐2 inhibitors that were …
the present study focuses on a series of pyrazole based VEGFR‐2 inhibitors that were …
[HTML][HTML] New quinoxaline-based VEGFR-2 inhibitors: Design, synthesis, and antiproliferative evaluation with in silico docking, ADMET, toxicity, and DFT studies
A new series of 3-methylquinoxaline-based derivatives having the same essential
pharmacophoric features as VEGFR-2 inhibitors have been synthesized and evaluated for …
pharmacophoric features as VEGFR-2 inhibitors have been synthesized and evaluated for …
[HTML][HTML] Discovery of new VEGFR-2 inhibitors: design, synthesis, anti-proliferative evaluation, docking, and MD simulation studies
EB Elkaeed, RG Yousef, MM Khalifa, A Ibrahim… - Molecules, 2022 - mdpi.com
Four new nicotinamide-based derivatives were designed as antiangiogenic VEGFR-2
inhibitors. The congeners were synthesized possessing the pharmacophoric essential …
inhibitors. The congeners were synthesized possessing the pharmacophoric essential …
Discovery of new 3-methylquinoxalines as potential anti-cancer agents and apoptosis inducers targeting VEGFR-2: design, synthesis, and in silico studies
There is an urgent need to design new anticancer agents that can prevent cancer cell
proliferation even with minimal side effects. Accordingly, two new series of 3 …
proliferation even with minimal side effects. Accordingly, two new series of 3 …
Discovery of new quinoline and isatine derivatives as potential VEGFR-2 inhibitors: Design, synthesis, antiproliferative, docking and MD simulation studies
A new set of quinoline and isatine derivatives were synthesized as antiangiogenic VEGFR-2
inhibitors. On a biological level, the in vitro ability of the obtained candidates to inhibit …
inhibitors. On a biological level, the in vitro ability of the obtained candidates to inhibit …
New thiazolidine-2, 4-diones as effective anti-proliferative and anti-VEGFR-2 agents: Design, synthesis, in vitro, docking, MD simulations, DFT, ADMET, and toxicity …
Abstract Novel thiazolidine-2, 4-dione derivatives, 11a-g, were designed, and synthesized
targeting the VEGFR-2 protein. The in vitro studies indicated the abilities of the synthesized …
targeting the VEGFR-2 protein. The in vitro studies indicated the abilities of the synthesized …
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