The medically important drug target galectin-3 binds galactose-containing moieties on
glycoproteins through an intricate pattern of hydrogen bonds to a largely polar surface …

The development of efficient galectin-3 (Gal-3) inhibitors draws attention in the field of anti-
cancer therapy, especially due to the prominent role of extra-and intracellular Gal-3 in vital …

Cellular communication events are mediated by interactions between cell-surface sugars
and lectins, which are carbohydrate-binding proteins. Galectins are β-galactosyl-binding …

Recent evidence has implicated galectins and their ligands as master regulators of immune
cell homeostasis. Whereas some members of this family, such as galectin-3, behave as …

Interactions between two cells or between cell and extracellular matrix mediated by protein–
carbohydrate interactions play pivotal roles in modulating various biological processes such …

Galectins constitute an evolutionary conserved family that bind to β-galactosides. Increasing
evidence shows that galectins are involved in many fundamental biological processes such …

Rationale: Galectin-3 (Gal-3) has been implicated in the development of pulmonary fibrosis
in experimental studies, and Gal-3 levels have been found to be elevated in small studies of …

A fragment-based development of 3C-triazol-1-yl-O-galactopyranosyl aldoximes led to the
discovery of highly selective and high affinity (Kd down to 11 μM) small monosaccharide …

Galectins have essential roles in pathological states including cancer, inflammation,
angiogenesis and microbial infections. Endogenous receptors include members of the lacto …

Publisher Summary Galectins are a family of 14 β-D-galactopyranoside-recognizing proteins
in mammals that have been shown to be important modulators of inflammatory processes …