Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis
P Vempati, AS Popel, F Mac Gabhann - BMC systems biology, 2011 - Springer
Background The spatial distribution of vascular endothelial growth factor A (VEGF) is an
important mediator of vascular patterning. Previous experimental studies in the mouse …
important mediator of vascular patterning. Previous experimental studies in the mouse …
Quantification and cell-to-cell variation of vascular endothelial growth factor receptors
PI Imoukhuede, AS Popel - Experimental cell research, 2011 - Elsevier
The vascular endothelial growth factor receptors (VEGFR) play a significant role in
angiogenesis, the formation of new blood vessels from existing vasculature. Systems …
angiogenesis, the formation of new blood vessels from existing vasculature. Systems …
Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport
FTH Wu, MO Stefanini, F Mac Gabhann… - Physiological …, 2009 - journals.physiology.org
Vascular endothelial growth factor (VEGF) signal transduction through the cell surface
receptors VEGFR1 and VEGFR2 regulates angiogenesis—the growth of new capillaries …
receptors VEGFR1 and VEGFR2 regulates angiogenesis—the growth of new capillaries …
Site-specific phosphorylation of VEGFR2 is mediated by receptor trafficking: insights from a computational model
LW Clegg, F Mac Gabhann - PLoS computational biology, 2015 - journals.plos.org
Matrix-binding isoforms and non-matrix-binding isoforms of vascular endothelial growth
factor (VEGF) are both capable of stimulating vascular remodeling, but the resulting blood …
factor (VEGF) are both capable of stimulating vascular remodeling, but the resulting blood …
[HTML][HTML] Computational modeling of interacting VEGF and soluble VEGF receptor concentration gradients
YL Hashambhoy, JC Chappell, SM Peirce… - Frontiers in …, 2011 - frontiersin.org
Experimental data indicates that soluble vascular endothelial growth factor (VEGF) receptor
1 (sFlt-1) modulates the guidance cues provided to sprouting blood vessels by VEGF-A. To …
1 (sFlt-1) modulates the guidance cues provided to sprouting blood vessels by VEGF-A. To …
The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signaling
MO Stefanini, FTH Wu, F Mac Gabhann… - PLoS computational …, 2009 - journals.plos.org
Vascular endothelial growth factor (VEGF) is a potent cytokine that binds to specific
receptors on the endothelial cells lining blood vessels. The signaling cascade triggered …
receptors on the endothelial cells lining blood vessels. The signaling cascade triggered …
Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning
P Vempati, AS Popel, F Mac Gabhann - Cytokine & growth factor reviews, 2014 - Elsevier
The regulation of vascular endothelial growth factor A (VEGF) is critical to
neovascularization in numerous tissues under physiological and pathological conditions …
neovascularization in numerous tissues under physiological and pathological conditions …
Computational model of vascular endothelial growth factor spatial distribution in muscle and pro-angiogenic cell therapy
F Mac Gabhann, JW Ji, AS Popel - PLoS computational biology, 2006 - journals.plos.org
Members of the vascular endothelial growth factor (VEGF) family of proteins are critical
regulators of angiogenesis. VEGF concentration gradients are important for activation and …
regulators of angiogenesis. VEGF concentration gradients are important for activation and …
A two-compartment model of VEGF distribution in the mouse
Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis–the growth of
new microvessels from existing microvasculature. Angiogenesis is a complex process …
new microvessels from existing microvasculature. Angiogenesis is a complex process …
Dynamics of VEGF matrix-retention in vascular network patterning
A Köhn-Luque, W De Back, Y Yamaguchi… - Physical …, 2013 - iopscience.iop.org
Vascular endothelial growth factor (VEGF) is a central regulator of blood vessel
morphogenesis, although its role in patterning of endothelial cells into vascular networks is …
morphogenesis, although its role in patterning of endothelial cells into vascular networks is …