Adaptation of bacterial pathogens to a permanently host‐associated lifestyle by means of
deletion or acquisition of genetic material is usually examined through comparison of …

High-throughput sequencing of transposon (Tn) libraries created within entire genomes
identifies and quantifies the contribution of individual genes and operons to the fitness of …

Abstract Background Adaptation of Pseudomonas aeruginosa to different living conditions is
accompanied by microevolution resulting in genomic diversity between strains of the same …

Bacterial pathogens evolve during the course of infection as they adapt to the selective
pressures that confront them inside the host. Identification of adaptive mutations and their …

This chapter focuses on the analysis of the factors driving the evolutive transition of
Pseudomonas aeruginosa populations from the acute to the chronic infection scenario and …

Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

Pseudomonas aeruginosa is one of the main microbial species colonizing the lungs of cystic
fibrosis patients and is responsible for the decline in respiratory function. Despite the hostile …

Pseudomonas aeruginosa is an opportunistic pathogen of humans and is a major cause of
morbidity and mortality in patients with cystic fibrosis (CF). Prolonged infection of the …

The ability to establish lifelong persistent infections is a fundamental aspect of the
interactions between many pathogenic microorganisms and their mammalian hosts. One …

In many human infections, hosts and pathogens coexist for years or decades. Important
examples include HIV, herpes viruses, tuberculosis, leprosy, and malaria. With the exception …