Adaptation is likely to be an important determinant of the success of many pathogens, for
example when colonizing a new host species, when challenged by antibiotic treatment, or in …

The bacterium Pseudomonas aeruginosa is a significant cause of acute nosocomial
infections as well as chronic respiratory infections in patients with cystic fibrosis (CF). Recent …

The genetic basis of bacterial adaptation to a natural environment has been investigated in
a highly successful Pseudomonas aeruginosa lineage (DK2) that evolved within the airways …

Background The constant increase in development and spread of bacterial resistance to
antibiotics poses a serious threat to human health. New sequencing technologies are now …

Antibiotic resistance has become a serious threat to human health (WHO Antibacterial
Agents in Clinical Development: an Analysis of the Antibacterial Clinical Development …

Pseudomonas aeruginosa is a Gram-negative environmental species and an opportunistic
microorganism, establishing itself in vulnerable patients, such as those with cystic fibrosis …

Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide range of acute
and chronic infections. An increasing number of isolates have mutations that make them …

We adapted PCR-based signature-tagged mutagenesis (STM) to Pseudomonas
aeruginosa. A collection of 1056 mutants was screened in a chronic lung infection rat model …

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen particularly
associated with the inherited disease cystic fibrosis (CF). Pseudomonas aeruginosa is well …

Advances in high-throughput DNA sequencing allow for a comprehensive analysis of
bacterial genes that contribute to virulence in a specific infectious setting. Such information …