Objective To present a recommended approach to the problem of “relative” adrenal
insufficiency (RAI) in the intensive care unit (ICU). Methods We examine historical data that …

Critically ill patients may develop glucocorticoid insufficiency at some stage. It encompasses
a decrease in glucocorticoid synthesis (ie, adrenal insufficiency) and peripheral resistance …

Objective: The definition of normal adrenal function in critically ill patients remains
controversial, despite a large body of literature. We review the clinical presentation …

Adequate adrenocortical function is essential to survive critical illness. Most critically ill
patients display an elevated plasma cortisol level, reflecting activation of the pituitary …

Objective To determine whether relative adrenal insufficiency (RAI) can be identified in
nonseptic hypotensive patients in the intensive care unit (ICU). Design Retrospective study …

Relative adrenal insufficiency in critical illness: a review... : Current Opinion in Endocrinology,
Diabetes and Obesity Relative adrenal insufficiency in critical illness: a review of the evidence …

Dysfunction of the hypothalamo-pituitary adrenal axis has become a central feature in
descriptions of the pathophysiology of sepsis. However, despite hundreds of published …

The definition of what constitutes a'normal'adrenal response to critical illness is unclear.
Consequently, published studies have used a variety of biochemical criteria to …

PURPOSE: To assess patterns of practice in our institution specifically regarding
corticosteroid deficiency diagnosis in patients with septic shock. METHODS: Consecutive …

Activation of the hypothalamo–pituitary–adrenal (HPA) axis, an integral component of the
stress response, results in an increase in plasma cortisol concentrations. In critical illness, a …