Individualized neuropathic pain therapy based on phenotyping: are we there yet?
J Forstenpointner, J Otto, R Baron - Pain, 2018 - journals.lww.com
Patients with the same neuropathic pain disorder may have completely different sensory
signs and symptoms yet receive the same medicinal treatment. New concepts suggest that …
signs and symptoms yet receive the same medicinal treatment. New concepts suggest that …
Phenotyping neuropathic pain patients: implications for individual therapy and clinical trials
M Reimer, SM Helfert, R Baron - Current opinion in supportive …, 2014 - journals.lww.com
The discussed trials show the importance of the development of an individualized pain
therapy. Up to now, no clinical trial has prospectively used the sensory phenotype as an …
therapy. Up to now, no clinical trial has prospectively used the sensory phenotype as an …
Individualized pharmacological treatment of neuropathic pain
SM Helfert, M Reimer, J Höper… - Clinical Pharmacology & …, 2015 - Wiley Online Library
Patients with the same disease may suffer from completely different pain symptoms yet
receive the same drug treatment. Several studies elucidate neuropathic pain and treatment …
receive the same drug treatment. Several studies elucidate neuropathic pain and treatment …
Sensory profiles: a new strategy for selecting patients in treatment trials for neuropathic pain
G Cruccu, A Truini - Pain, 2009 - journals.lww.com
Unlike the plethora of drugs available to treat epilepsy, depression, or migraine,
comparatively few and insufficiently effective drugs are available for neuropathic pain …
comparatively few and insufficiently effective drugs are available for neuropathic pain …
Pain phenotype as a predictor for drug response in painful polyneuropathy—a retrospective analysis of data from controlled clinical trials
JV Holbech, FW Bach, NB Finnerup, TS Jensen… - Pain, 2016 - journals.lww.com
The drugs available for treatment of neuropathic pain have somewhat disappointing efficacy
with many patients left with limited or no effect. Individualized treatment based on phenotype …
with many patients left with limited or no effect. Individualized treatment based on phenotype …
Personalized treatment of neuropathic pain: Where are we now?
D Bouhassira, N Attal - European Journal of Pain, 2023 - Wiley Online Library
Background The treatment of neuropathic pain remains a major unmet need that the
development of personalized and refined treatment strategies may contribute to address …
development of personalized and refined treatment strategies may contribute to address …
Stratification of patients based on the Neuropathic Pain Symptom Inventory: development and validation of a new algorithm
The personalization of neuropathic pain treatment could be improved by identifying specific
sensory phenotypes (ie, specific combinations of symptoms and signs) predictive of the …
sensory phenotypes (ie, specific combinations of symptoms and signs) predictive of the …
Evaluation of symptom heterogeneity in neuropathic pain using assessments of sensory functions
K Arning, R Baron - Neurotherapeutics, 2009 - Springer
Classification of neuropathic pain has been based on disease entities, anatomical
localization, or histological observations. Over the past decade, there has been an explosion …
localization, or histological observations. Over the past decade, there has been an explosion …
Maximizing treatment efficacy through patient stratification in neuropathic pain trials
R Baron, AH Dickenson, M Calvo, SD Dib-Hajj… - Nature Reviews …, 2023 - nature.com
Abstract Treatment of neuropathic pain remains inadequate despite the elucidation of
multiple pathophysiological mechanisms and the development of promising therapeutic …
multiple pathophysiological mechanisms and the development of promising therapeutic …
Neuropathic pain: a clinical perspective
R Baron - Sensory Nerves, 2009 - Springer
Neuropathic pain syndromes, ie, pain after a lesion or disease of the peripheral or central
nervous system, are clinically characterized by spontaneous pain (ongoing, paroxysms) and …
nervous system, are clinically characterized by spontaneous pain (ongoing, paroxysms) and …