[HTML][HTML] RNA-Seq identifies marked Th17 cell activation and altered CFTR expression in different atopic dermatitis subtypes in Chinese Han populations

X Tian, B Liu, L Chen, Y Xie, J Liang, Y Yang… - Frontiers in …, 2021 - frontiersin.org
Background Patients with atopic dermatitis (AD) exhibit phenotypic variability in ethnicity and
IgE status. In addition, some patients develop other allergic conditions, such as allergic …

Single‐cell RNA‐seq reveals abnormal differentiation of keratinocytes and increased inflammatory differentiated keratinocytes in atopic dermatitis

J Zhou, G Liang, L Liu, S Feng, Z Zheng… - Journal of the …, 2023 - Wiley Online Library
Background Atopic dermatitis (AD) is a chronic and recurrent inflammatory skin disease
characterized by severe pruritus and eczematous lesions. Heterogeneity of AD has been …

The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization

S Noda, M Suárez-Fariñas, B Ungar, SJ Kim… - Journal of Allergy and …, 2015 - Elsevier
Background Atopic dermatitis (AD) shows very high prevalence in Asia, with a large unmet
need for effective therapeutics. Direct comparisons between European American (EA) and …

Atopic dermatitis in African American patients is TH2/TH22-skewed with TH1/TH17 attenuation

RD Sanyal, AB Pavel, J Glickman, TC Chan… - Annals of Allergy …, 2019 - Elsevier
Abstract Background African Americans (AA) are disproportionately impacted by atopic
dermatitis (AD), with increased prevalence and therapeutic challenges unique to this …

[HTML][HTML] Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation

S Wongvibulsin, N Sutaria, S Kannan, MP Alphonse… - Scientific reports, 2021 - nature.com
Atopic dermatitis (AD) often presents more severely in African Americans (AAs) and with
greater involvement of extensor areas. To investigate immune signatures of AD in AAs with …

Single‐cell profiles reveal distinctive immune response in atopic dermatitis in contrast to psoriasis

B Zhang, LM Roesner, S Traidl, VACM Koeken, CJ Xu… - Allergy, 2023 - Wiley Online Library
Background Understanding the complex orchestrated inflammation in atopic dermatitis (AD),
one of the most common chronic inflammatory diseases worldwide, is essential for …

Multipolarity of cytokine axes in the pathogenesis of atopic dermatitis in terms of age, race, species, disease stage and biomarkers

T Nomura, T Honda, K Kabashima - International immunology, 2018 - academic.oup.com
Atopic dermatitis (AD) is a common T-cell-mediated inflammatory disease of the skin.
Signatures of AD are characterized by an impaired skin barrier, aberrant Th2-type cytokine …

Possible role of Th17 cells and IL-17 in the pathogenesis of atopic dermatitis in northern China

L Ma, HB Xue, XH Guan, RQ Qi, RZ An… - Journal of …, 2012 - jdsjournal.com
Atopic dermatitis (AD) is a common, chronic relapsing, inflammatory skin disease, which is
usually associated with other systemic atopic disorders such as allergic asthma and rhinitis …

RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications

M Suárez-Fariñas, B Ungar, JC da Rosa… - Journal of Allergy and …, 2015 - Elsevier
Background Genomic profiling of lesional and nonlesional skin of patients with atopic
dermatitis (AD) using microarrays has led to increased understanding of AD and …

[HTML][HTML] Atopic dermatitis is an IL-13–dominant disease with greater molecular heterogeneity compared to psoriasis

LC Tsoi, E Rodriguez, F Degenhardt, H Baurecht… - Journal of Investigative …, 2019 - Elsevier
Atopic dermatitis (AD) affects up to 20% of children and adults worldwide. To gain a deeper
understanding of the pathophysiology of AD, we conducted a large-scale transcriptomic …