Layer-by-layer microfluidics for biomimetic three-dimensional structures

W Tan, TA Desai - Biomaterials, 2004 - Elsevier
Due to the complex structures of living systems, with size scales spanning from the micron to
millimeter range, the use of microtechnology to recreate in vivo-like architecture has exciting …

Microfluidic patterning of cellular biopolymer matrices for biomimetic 3-D structures

W Tan, TA Desai - Biomedical Microdevices, 2003 - Springer
Microtechnology has found exciting potential applications in recreating in vivo tissue
architecture due to its ability to create complex structures with size scales spanning from the …

Microscale multilayer cocultures for biomimetic blood vessels

W Tan, TA Desai - … of Biomedical Materials Research Part A: An …, 2005 - Wiley Online Library
Living tissues have complex and well‐organized microstructures. Although microtechnology
has been used to create in vivo‐like cell microstructures in vitro, most available microscale …

Rapid prototyping of multilayer microphysiological systems

S Hosic, AJ Bindas, ML Puzan, W Lake… - ACS biomaterials …, 2020 - ACS Publications
Microfluidic organs-on-chips aim to realize more biorelevant in vitro experiments compared
to traditional two-dimensional (2D) static cell culture. Often such devices are fabricated via …

Microfabricated biomaterials for engineering 3D tissues

P Zorlutuna, N Annabi, G Camci‐Unal… - Advanced …, 2012 - Wiley Online Library
Mimicking natural tissue structure is crucial for engineered tissues with intended
applications ranging from regenerative medicine to biorobotics. Native tissues are highly …

Advances of microfluidics in biomedical engineering

Q Zhong, H Ding, B Gao, Z He… - Advanced materials …, 2019 - Wiley Online Library
As an enabling technique, microfluidic systems have developed rapidly in recent years to
emerge as a powerful tool in the field of biomedical engineering. Microfluidics enables …

Engineering of a microfluidic cell culture platform embedded with nanoscale features

Y Yang, K Kulangara, J Sia, L Wang, KW Leong - Lab on a Chip, 2011 - pubs.rsc.org
Cells residing in a microenvironment interact with the extracellular matrix (ECM) and
neighboring cells. The ECM built from biomacromolecules often includes nanotopography …

The crossing and integration between microfluidic technology and 3D printing for organ-on-chips

S Mi, Z Du, Y Xu, W Sun - Journal of Materials Chemistry B, 2018 - pubs.rsc.org
Organ-on-chips were designed to simulate the real tissue or organ microenvironment by
precise control of the cells, the extracellular matrix and other micro-environmental factors to …

Biomaterials-based microfluidics for engineered tissue constructs

CJ Bettinger, JT Borenstein - Soft Matter, 2010 - pubs.rsc.org
The utility of microfluidics in biotechnology has dramatically increased in recent years as
these systems have expanded to supplement efforts in lab-on-a-chip technology. The driving …

Microfluidic technologies for vasculature biomimicry

C Hu, Y Chen, MJA Tan, K Ren, H Wu - Analyst, 2019 - pubs.rsc.org
Microfluidic technology has been extensively employed in biology and medicine since the
field emerged in the 1990s. By utilizing microfluidic approaches, a variety of vascular system …